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Danazol in the treatment of systemic lupus erythematosus: a qualitative systematic review.

Author: LetchumananPagalavan, ThumbooJulian

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Danazol has been found to be a useful treatment option for hematologic manifestations of systemic lupus erythematosus (SLE), particularly for refractory thrombocytopenia, autoimmune hemolytic anemia, and premenstrual flares. While limited information is available on its use for non-hematologic manifestations, danazol appears to be well-tolerated and safe, with manageable adverse effects.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To review and summarize published information on the use, effectiveness, and adverse effects of danazol in patients with systemic lupus erythematosus (SLE). METHODS: A MEDLINE search from January 1950 to July 2009 was conducted using 2 search strategies retrieving 51 and 62 references, ...See full text at original site
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引用元：
https://doi.org/10.1016/j.semarthrit.2010.03.005

データ提供：米国国立医学図書館（NLM）

Danazol for Systemic Lupus Erythematosus

This review summarizes published information on the use, effectiveness, and adverse effects of danazol for the treatment of systemic lupus erythematosus (SLE). SLE is a chronic autoimmune disease that can affect various parts of the body, including the skin, joints, kidneys, and brain. Danazol, a synthetic steroid, has been investigated for its potential to suppress the immune system and reduce inflammation in SLE patients.

Danazol's Effectiveness in SLE

This review highlights that danazol has been successfully used in treating certain manifestations of SLE, particularly hematologic complications like thrombocytopenia, autoimmune hemolytic anemia, and Evan's syndrome. Danazol has also been shown to be helpful in some patients with mild nonhematologic manifestations of SLE. However, the review notes that there is limited information on the use of danazol in nonhematologic manifestations of SLE, and more research is needed to fully understand its role in managing the disease.

Health Implications and Lifestyle Considerations

As with any medication, danazol can have side effects. High doses of danazol may cause undesirable side effects for female patients. It is crucial to discuss the potential benefits and risks of danazol treatment with your healthcare provider, who can help you weigh the potential benefits against the potential risks.

Dr.Camel's Conclusion

This review suggests that danazol can be a valuable treatment option for some SLE patients, particularly those experiencing hematologic complications. However, it is important to weigh the potential benefits against the potential risks and to discuss treatment options with a healthcare provider. Further research is needed to fully understand the effectiveness and safety of danazol in treating SLE.
Date :
  1. Date Completed 2011-05-12
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20541792

DOI: Digital Object Identifier

10.1016/j.semarthrit.2010.03.005

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Languages

English

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