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Lysophosphatidic acid is a potential mediator of cholestatic pruritus.

Author: BeuersUlrich, GeenesVictoria L, KondrackieneJurate, KremerAndreas E, KuiperEdith M M, KulikWim, MartensJob J W W, MoolenaarWouter H, Oude ElferinkRonald P J, PrietoJesus, RustChristian, RuëffFranziska, WilliamsonCatherine, van BuurenHenk R, van ErpecumKarel J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lysophosphatidic acid (LPA) and autotaxin may play a critical role in cholestatic pruritus and may serve as potential targets for future therapeutic interventions. This study found that LPA concentrations were increased in cholestatic patients with pruritus and that autotaxin activity correlated with intensity of pruritus.
Paper Details　
Original Abstract of the Article :
BACKGROUND & AIMS: Pruritus is a common and disabling symptom in cholestatic disorders. However, its causes remain unknown. We hypothesized that potential pruritogens accumulate in the circulation of cholestatic patients and activate sensory neurons. METHODS: Cytosolic free calcium ([Ca(2+)](i)) wa...See full text at original site
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引用元：
https://doi.org/10.1053/j.gastro.2010.05.009

データ提供：米国国立医学図書館（NLM）

Lysophosphatidic Acid: A Potential Key to Understanding Cholestatic Pruritus

Cholestatic disorders, characterized by impaired bile flow, can cause intense and debilitating itching, known as pruritus. This study investigated the potential role of lysophosphatidic acid (LPA) in mediating cholestatic pruritus. The researchers found that LPA levels were elevated in the serum of patients with cholestatic disorders experiencing pruritus, suggesting a potential link between LPA and this symptom.

Unraveling the Mystery: LPA and Cholestatic Pruritus

The study found that serum samples from patients with cholestatic disorders and pruritus induced transient increases in neuronal cytosolic free calcium ([Ca(2+)](i)), a marker of neuronal activation. They further identified LPA as a major [Ca(2+)](i)-inducing factor in these serum samples and discovered that LPA concentrations were elevated in cholestatic patients with pruritus. Additionally, the study showed that LPA injection into mice induced scratching behavior, further supporting its role in pruritus.

Seeking Relief: Future Therapeutic Targets

This study provides compelling evidence for the potential role of LPA in mediating cholestatic pruritus. The findings suggest that LPA and its precursor enzyme, autotaxin, could be potential targets for future therapeutic interventions aimed at alleviating the debilitating itching associated with cholestatic disorders. Further research is needed to explore the clinical implications of these findings and to develop effective therapies targeting LPA and autotaxin.

Dr.Camel's Conclusion

Like a camel seeking water in the desert, researchers are diligently searching for solutions to alleviate the intense itching associated with cholestatic disorders. This study sheds light on the potential role of LPA in mediating pruritus, opening up exciting possibilities for developing new and effective treatments for this debilitating condition. The future holds promise for finding relief from this persistent and often overlooked symptom, improving the quality of life for patients suffering from cholestatic disorders.

Date :
  1. Date Completed 2010-09-20
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

20546739

DOI: Digital Object Identifier

10.1053/j.gastro.2010.05.009

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