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Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.

Author: , BautistaRaúl, CaballeroJosé, CoatsTim, DewanYashbir, El-SayedHesham, GogichaishviliTamar, GuptaSanjay, HerreraJorge, HuntBeverley, IribhogbePius, IzurietaMario, KhamisHussein, KomolafeEdward, MarreroMaría-Acelia, Mejía-MantillaJorge, MirandaJaime, MoralesCarlos, OlaomiOluwole, OlldashiFatos, PerelPablo, PetoRichard, RamanaP V, RaviR R, RobertsIan, ShakurHaleema, YutthakasemsuntSurakrant

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This randomized controlled trial found that tranexamic acid safely reduced the risk of death in bleeding trauma patients. On the basis of these results, tranexamic acid should be considered for use in bleeding trauma patients.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Tranexamic acid can reduce bleeding in patients undergoing elective surgery. We assessed the effects of early administration of a short course of tranexamic acid on death, vascular occlusive events, and the receipt of blood transfusion in trauma patients. METHODS: This randomised contro...See full text at original site
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引用元：
https://doi.org/10.1016/S0140-6736(10)60835-5

データ提供：米国国立医学図書館（NLM）

Tranexamic Acid: A Lifesaver for Trauma Patients with Bleeding

This groundbreaking study, conducted in a large international collaboration, investigated the impact of early tranexamic acid administration on survival in trauma patients with significant bleeding. The authors randomly assigned over 20,000 patients to receive either tranexamic acid or placebo within 8 hours of injury. Their findings revealed a significant reduction in all-cause mortality among patients receiving tranexamic acid, suggesting that this drug can be a life-saving intervention for trauma patients with bleeding. The study emphasizes the importance of timely intervention in trauma care and highlights the potential of tranexamic acid as a crucial tool for improving survival rates in these patients.

Saving Lives in the Desert of Trauma

This research demonstrates the significant benefits of early tranexamic acid administration in trauma patients with significant bleeding. The study's findings highlight the importance of timely intervention in trauma care, with tranexamic acid emerging as a vital tool for improving survival rates in these patients.

A Lifeline in the Desert

Like a camel finding a hidden oasis in a desolate desert, trauma patients with bleeding can find a lifeline in tranexamic acid. This research confirms its life-saving potential, providing a crucial tool for medical professionals to improve outcomes for patients facing the challenges of trauma.

Dr. Camel's Conclusion

This landmark study reveals the life-saving potential of tranexamic acid in trauma patients with significant bleeding. The findings underscore the importance of timely intervention and highlight the drug's ability to reduce all-cause mortality in these patients. This research is a testament to the power of collaborative research and its ability to improve outcomes for individuals facing life-threatening situations.
Date :
  1. Date Completed 2010-07-20
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

20554319

DOI: Digital Object Identifier

10.1016/S0140-6736(10)60835-5

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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