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Studies on the mode of action of tolnaftate in Microsporum gypseum.
Author: BalaI, GuptaM P, KapurN, KhullerG K
Original Abstract of the Article :
Studies were performed on the mode of action of tolnaftate and resistance to this drug in Microsporum gypseum. Cells grown in the presence of tolnaftate (at the IC 50) showed a reduced content of total phospholipids and sterols whereas there was an increase in total RNA content. Incubation of cells ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1080/02681219180000081
データ提供:米国国立医学図書館(NLM)
Unraveling the Secrets of Tolnaftate: Insights into Antifungal Action
The development of [antifungal drugs] is crucial for treating a wide range of fungal infections. This research investigates the [mode of action] of [tolnaftate] against the fungal pathogen [Microsporum gypseum]. The study explores the impact of tolnaftate on various cellular components and metabolic processes, including phospholipids, sterols, RNA, and membrane-bound enzymes. The researchers also investigate the development of [tolnaftate resistance] in M. gypseum, providing insights into the mechanisms underlying drug resistance.
A Journey Through the Fungus: Understanding Drug Action
This research delves into the intricate world of antifungal action. Just as a camel traverses a desert, seeking out hidden sources of water, this study explores the pathways and mechanisms by which tolnaftate combats fungal infections. The research sheds light on the diverse targets and mechanisms by which this antifungal drug exerts its effects.
Antimicrobial Resistance: A Growing Challenge
This research highlights the growing challenge of [antimicrobial resistance]. Just as a desert can become barren and uninhabitable due to desertification, antimicrobial resistance threatens our ability to combat infectious diseases effectively. This study emphasizes the need for continued research to understand and overcome the mechanisms of drug resistance.
Dr. Camel's Conclusion
This research on tolnaftate and fungal resistance is a reminder that the battle against infectious diseases is an ongoing one. Just as a camel adapts to survive in the harsh desert environment, we must continually strive to understand and overcome the challenges posed by antimicrobial resistance.
Date :
- Date Completed 1991-08-08
- Date Revised 2019-10-29
Further Info :
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English
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