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Steroid-sparing effects with allergen-specific immunotherapy in children with asthma: a randomized controlled trial.

Author: KardosPeter, MadoniniEnzo, ZielenStefan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Adding a mite allergoid subcutaneous immunotherapy (SCIT) to pharmacologic treatment was an effective and safe strategy to reduce corticosteroid doses while maintaining disease control in children with mite-induced allergic asthma.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Asthma control is now recognized as the main goal of asthma therapy. Guidelines recommend finding the lowest effective dose of inhaled corticosteroids in children with persistent asthma. OBJECTIVE: The aim of this study was to investigate the efficacy of an allergen-specific immunothera...See full text at original site
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引用元：
https://doi.org/10.1016/j.jaci.2010.06.002

データ提供：米国国立医学図書館（NLM）

Allergen-Specific Immunotherapy: A Potential Steroid-Sparing Strategy for Asthma

Asthma is a chronic respiratory condition that affects millions worldwide. Treatment often involves inhaled corticosteroids, which can effectively control symptoms but can also have side effects. Allergen-specific immunotherapy (AIT) is a treatment that aims to desensitize individuals to specific allergens, potentially reducing the need for corticosteroids. This study investigates the steroid-sparing effects of AIT in children with asthma.

The researchers conducted a randomized controlled trial comparing a group of children who received AIT in addition to inhaled corticosteroids to a group who received inhaled corticosteroids alone. They measured the changes in corticosteroid dosages and asthma control over a two-year period.

AIT: A Step Toward Reduced Steroid Dependence

The study found that children receiving AIT were able to significantly reduce their inhaled corticosteroid doses while maintaining good asthma control. The study also demonstrated that AIT led to improvements in lung function and a significant increase in specific IgG antibodies, which suggests an immune response to the allergen.

A Promising Approach for Asthma Management

The study's findings offer hope for children with asthma, suggesting that AIT could potentially reduce their reliance on corticosteroids and improve overall asthma control. However, further research is needed to confirm the long-term efficacy and safety of AIT in different age groups and with various allergens.

Dr. Camel's Conclusion

This study highlights the exciting potential of AIT as a steroid-sparing strategy for children with asthma. By reducing the need for corticosteroids, AIT could potentially improve patient quality of life and minimize the risk of long-term side effects. However, more research is needed to validate these findings and establish the optimal use of AIT in different asthma populations.

Date :
  1. Date Completed 2010-12-10
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

20624650

DOI: Digital Object Identifier

10.1016/j.jaci.2010.06.002

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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