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Population pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief of chronic pain.

Author: AartsLeon, BauerMartin, DahanAlbert, NiestersMarieke, NoppersIngeborg, OlofsenErik, SartonElise, SigtermansMarnix

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This pharmacokinetic-pharmacodynamic (PK-PD) modeling study examined the effect of S(+)-ketamine on pain scores in Complex Regional Pain Syndrome type 1 (CRPS-1) patients.
Paper Details　
Original Abstract of the Article :
Pharmacological treatment of chronic (neuropathic) pain is often disappointing. In order to enhance our insight in the complex interaction between analgesic drug and chronic pain relief, we performed a pharmacokinetic-pharmacodynamic (PK-PD) modeling study on the effect of S(+)-ketamine on pain scor...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejpain.2010.06.016

データ提供：米国国立医学図書館（NLM）

Pharmacokinetic-Pharmacodynamic Modeling of Ketamine-Induced Pain Relief

[Chronic pain] is a debilitating condition that can significantly impact quality of life. This study explores the [pharmacokinetic-pharmacodynamic (PK-PD) relationship] of [ketamine] in the treatment of [chronic pain], specifically in patients with [Complex Regional Pain Syndrome type 1 (CRPS-1)]. This research provides valuable insights into the [efficacy and mechanisms of action] of ketamine in managing chronic pain.

Understanding the Relationship Between Drugs and Pain

[Pain] is a complex phenomenon involving [multiple physiological and psychological factors]. Understanding the [relationship between drugs and pain] is crucial for developing [effective pain management strategies]. This study sheds light on the [PK-PD profile of ketamine] and its [potential for treating chronic pain].

Managing Chronic Pain

[Chronic pain] can be a challenging condition to manage. It is essential to [work with your doctor] to develop a [personalized treatment plan] that addresses your individual needs. This may involve [medication, therapy, lifestyle modifications, and other pain management techniques]. Remember that there are [many resources available] to help you manage your pain and improve your quality of life.

Dr.Camel's Conclusion

The journey of chronic pain can be long and arduous, like a camel crossing a vast and unforgiving desert. This research offers valuable insights into the use of ketamine for pain relief, highlighting the importance of understanding the complex interplay between drugs and pain. As we continue to explore the intricacies of pain management, we can develop more effective treatments and provide greater hope for those living with chronic pain.
Date :
  1. Date Completed 2011-08-23
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

20638877

DOI: Digital Object Identifier

10.1016/j.ejpain.2010.06.016

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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