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Acute severe ulcerative colitis in children: a systematic review.

Author: GriffithsAnne M, TurnerDan

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study examines the treatment of ulcerative colitis (UC) in children, highlighting that it is often more severe than in adults, with more widespread disease and frequent severe flare-ups. The study summarizes key findings on treatment approaches, including: - Steroids are commonly used, with a 34% failure rate, and are generally recommended at doses of 1-1.5 mg/kg per day. - Restricting food is not typically helpful and is discouraged unless there are surgical concerns. - The Pediatric UC Activity Index (PUCAI) can help predict which children are likely to need additional medications. - Cyclosporine can be effective for short-term treatment, with an 81% success rate, but should be used for a limited time while transitioning to another medication. - Infliximab is also effective, with a 75% short-term and 64% one-year success rate. - Surgery (colectomy) may be necessary in severe cases, with considerations for long-term medication side effects, quality of life, and fertility for female patients.
Paper Details　
Original Abstract of the Article :
Pediatric ulcerative colitis (UC) has a more severe phenotype, reflected by more extensive disease and a higher rate of acute severe exacerbations. The pooled steroid-failure rate among 291 children from five studies is 34% (95% confidence interval [CI]: 27%-41%). It is suggested that corticosteroid...See full text at original site
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引用元：
https://doi.org/10.1002/ibd.21383

データ提供：米国国立医学図書館（NLM）

Navigating the Complexities of Pediatric Ulcerative Colitis

Ulcerative colitis, a chronic inflammatory bowel disease, can be particularly challenging in children. This study delves into the complexities of acute severe ulcerative colitis in children, examining treatment approaches and outcomes. The researchers analyzed data from numerous studies, meticulously mapping out the path to effective treatment, like a camel carefully charting its course through a vast and unforgiving desert.

The study revealed that pediatric ulcerative colitis often presents with a more severe phenotype, requiring specialized management strategies. The researchers found that corticosteroids, a common treatment for severe ulcerative colitis, may not be effective for all children, emphasizing the need for individualized treatment plans. It's like a camel encountering a dry riverbed: what may work for one camel may not be suitable for another, and the journey requires flexibility and adaptability.

Personalized Treatment for Children

The study's findings underscore the importance of tailoring treatment to the individual needs of each child with ulcerative colitis. This personalized approach, like a camel carefully selecting the best grazing spot, ensures that the treatment plan is tailored to the child's unique condition and circumstances.

Understanding the Challenges of Pediatric Ulcerative Colitis

The study highlights the challenges associated with managing pediatric ulcerative colitis, emphasizing the need for continued research and innovation. By understanding the complexities of this disease, we can develop more effective treatments and improve the quality of life for children and their families.

Dr.Camel's Conclusion

This study provides valuable insights into the complexities of pediatric ulcerative colitis. It underscores the importance of individualized treatment plans and ongoing research to improve the care and well-being of children living with this chronic condition. Like a camel navigating a treacherous desert, the journey to effective treatment requires patience, persistence, and a deep understanding of the terrain ahead.

Date :
  1. Date Completed 2011-05-12
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

20645317

DOI: Digital Object Identifier

10.1002/ibd.21383

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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