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Methylnaltrexone: the evidence for its use in the management of opioid-induced constipation.

Author: BeckerGerhild, BlumHubert E, DeibertPeter, XanderCarola

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Constipation is a common side effect of opioid treatment. New drugs are needed to prevent or treat constipation without compromising the efficacy of opioid analgesics.
Paper Details　
Original Abstract of the Article :
Constipation is a distressing side effect of opioid treatment, being so irksome in some cases that patients would rather suffer the pain than the side effect of opioid analgesics. Stool softeners or stimulating laxatives are often ineffective or even aggravate the situation. A new efficacious and sa...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899781/

データ提供：米国国立医学図書館（NLM）

Methylnaltrexone: A Ray of Hope for Opioid-Induced Constipation

Opioid-induced constipation (OIC) is a common and often troublesome side effect of opioid therapy. This study reviews the evidence supporting the use of methylnaltrexone, a peripheral opioid receptor antagonist, in managing OIC. The authors examine the efficacy and safety of methylnaltrexone in alleviating constipation associated with opioid use.

A Targeted Approach to OIC: The Benefits of Methylnaltrexone

The study highlights the efficacy of methylnaltrexone in managing OIC, demonstrating its ability to relieve constipation without affecting the analgesic effects of opioids. This targeted approach offers a significant improvement in the quality of life for patients experiencing OIC.

Navigating the Desert of OIC: Methylnaltrexone Provides a Path to Relief

This research underscores the importance of finding effective solutions for managing OIC. Methylnaltrexone offers a valuable tool for clinicians to address this common side effect, improving the overall well-being of patients undergoing opioid therapy.

Dr. Camel's Conclusion

The desert of OIC can be a harsh and uncomfortable place. Methylnaltrexone offers a refreshing oasis, providing a targeted approach to relieve constipation without compromising the benefits of opioid analgesia. This research is a reminder that even in the most challenging medical situations, there is always a chance for a brighter horizon.

Date :
  1. Date Completed 2011-07-14
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20694079

DOI: Digital Object Identifier

PMC2899781

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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