Paper Details
- Home
- Paper Details
A possible mechanism of toxicity by the antidepressant amoxapine based on its effects in three in vitro models.
Author: CooperG J, FergusonL R, LoiselleD S, RobertonA M
Original Abstract of the Article :
When the antidepressant amoxapine is taken in overdose, it can cause metabolic acidosis, brain damage and sometimes death. In previous studies, biochemical evidence has been presented that amoxapine disrupts reactions of membrane-associated multi-enzyme complexes, and mitochondrial energy conservati...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/0887-2333(89)90035-0
データ提供:米国国立医学図書館(NLM)
Unraveling the Mystery Behind Amoxapine Toxicity
Amoxapine is a medication that can be quite helpful in treating depression, but like a mirage in the desert, it can sometimes be deceiving. When taken in excessive amounts, it can have serious side effects. This study delves into the potential mechanisms behind amoxapine's toxicity, seeking to shed light on how it can cause harm.
The researchers are interested in understanding how amoxapine disrupts cellular processes, particularly those involving energy production. They used several models to observe the effects of amoxapine on cells, focusing on its impact on oxygen uptake, lactic acid accumulation, and overall cell survival.
Their findings suggest that amoxapine disrupts cellular energy conservation, leading to various adverse effects. They observed that amoxapine can interfere with oxygen uptake and even cause cell death. This disruption in cellular energy production could be the root cause of the toxicity observed in cases of amoxapine overdose.
Understanding the Unseen Impact
This research sheds light on the complex mechanisms behind amoxapine's toxicity. By understanding these mechanisms, we can better predict and potentially prevent harmful side effects.
Navigating Medication Safely
Always take your medications as prescribed by your doctor, and be sure to communicate any concerns you have. This study reminds us that even medications with positive effects can have unintended consequences when not used appropriately.
Dr. Camel's Conclusion
The desert of medicine can be tricky to navigate. It's important to understand the potential dangers of medications, even those that seem harmless. Remember, the key to a successful journey is always to seek guidance from your doctor, stay informed, and stay safe.
Date :
- Date Completed 2012-10-02
- Date Revised 2019-09-18
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.