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Synthesis, characterization, and in vivo evaluation of poly(ethylene oxide-co-glycidol)-platinate conjugate.

Author: ChauYing, LiZhongyu, ZhouPing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Poly(EO-co-Gly) is a new biocompatible material that can be used as a drug carrier. Poly(EO-co-Gly)-platinate, a polymer-drug conjugate of poly(EO-co-Gly) and cisplatin, was shown to be effective in treating cancer in mice.
Paper Details　
Original Abstract of the Article :
Poly(ethylene oxide-co-glycidol) (poly(EO-co-Gly)), a member of polyether polyol (PEP), resembles polyethylene glycol (PEG) in the polymer backbone but distinguishes itself by having multiple pendent groups along the main chain. We showed that this new bioconjugation material is biocompatible by its...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejps.2010.07.014

データ提供：米国国立医学図書館（NLM）

Poly(ethylene oxide-co-glycidol)-platinate: A New Drug Delivery System

Cancer treatment is often a grueling journey through a desert of side effects and uncertainties. This study introduces a promising new drug delivery system using poly(ethylene oxide-co-glycidol)-platinate, a novel conjugate that aims to improve the effectiveness and reduce the toxicity of platinum-based chemotherapy. Like finding a water source in a parched landscape, this new approach seeks to enhance the delivery of anti-cancer drugs while minimizing the negative impacts on healthy tissues.

A New Oasis for Cancer Treatment

This research explores a novel approach to cancer treatment, potentially offering a more targeted and less toxic way to deliver anti-cancer drugs. It's like discovering a new oasis in a vast desert, offering a haven from the harsh realities of cancer therapy. The researchers' findings highlight the potential for this new drug delivery system to improve patient outcomes and quality of life.

The Promise of Poly(ethylene oxide-co-glycidol)-platinate

This study suggests that poly(ethylene oxide-co-glycidol)-platinate could be a valuable tool for improving the efficacy and reducing the side effects of platinum-based chemotherapy. It's like building a bridge across a treacherous desert, enabling a safer and more effective journey to recovery. The researchers' findings offer a potential solution for addressing the challenges of cancer treatment, paving the way for more effective and less toxic therapies.

Dr.Camel's Conclusion

This study unveils a promising new drug delivery system that could significantly improve the lives of cancer patients. The researchers' findings highlight the potential for this innovative approach to deliver anti-cancer drugs more effectively while minimizing harmful side effects. It's a step forward in the ongoing quest for better cancer treatments, offering a glimmer of hope in the desert of this challenging disease.
Date :
  1. Date Completed 2011-02-07
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20709170

DOI: Digital Object Identifier

10.1016/j.ejps.2010.07.014

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Languages

English

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