An antibody against RANKL for the treatment of osteoporosis, inflammatory and malignant bone diseases.

Author: Maldonado-GonzalesEduardo, PietschmannPeter

Paper Details 
Original Abstract of the Article :
Over the years, the importance of receptor activator of nuclear factor κB ligand (RANKL) in bone physiology and pathophysiology has been thoroughly documented. Denosumab, also known as AMG 162, is a fully human monoclonal antibody against RANKL which is being studied in the treatment of metabolic, i...See full text at original site
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引用元:
https://doi.org/10.1007/s10354-010-0812-3

データ提供:米国国立医学図書館(NLM)

Denosumab: A Powerful Weapon Against Bone Diseases

Bone health is a crucial aspect of overall well-being, and a variety of conditions, such as osteoporosis, rheumatoid arthritis, and bone metastases, can affect skeletal integrity. This study explores the potential of denosumab, a fully human monoclonal antibody against RANKL, a key regulator of bone metabolism, as a therapeutic agent for these bone diseases.

Targeting RANKL for Bone Health

The researchers found that denosumab effectively inhibits RANKL, which plays a crucial role in bone resorption, the process of bone breakdown. This inhibition leads to a reduction in bone loss, potentially mitigating the detrimental effects of various bone diseases.

A Promising Treatment for Bone Diseases

Denosumab, with its targeted approach to bone metabolism, has emerged as a promising treatment for osteoporosis, rheumatoid arthritis, bone metastases, and multiple myeloma. This targeted therapy offers a potential alternative to conventional treatments, with the potential for improved efficacy and fewer side effects.

Dr.Camel's Conclusion

This study is a testament to the remarkable advancements in our understanding of bone biology and the development of targeted therapies. Denosumab, with its ability to effectively target RANKL, offers a ray of hope for those struggling with bone diseases. Just as a desert traveler finds refuge in a well-maintained oasis, denosumab provides a promising path toward healthier bones and a better quality of life.

Date :
  1. Date Completed 2011-03-22
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20714812

DOI: Digital Object Identifier

10.1007/s10354-010-0812-3

Related Literature

SNS
PICO Info
in preparation
Languages

English

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