Effective treatment of bone diseases: A Synthesis of Findings from 24 Studies

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Original Abstract of the Article

Main Research Findings

Lactoferrin (Lf) is a multifunctional protein that plays a crucial role in bone remodeling by regulating the function of osteoblasts, chondrocytes, osteoclasts, and mesenchymal stem cells. 3

Lf promotes osteoblast proliferation, differentiation, and mineralization, while inhibiting osteoclast differentiation and activity. 3

Lf accelerates fracture repair by stimulating osteoblast and chondrocyte activity and inhibiting osteoclast function. 3

Layered double hydroxides (LDHs) are a novel promising 2D nanomaterial for the treatment of bone diseases. 4

LDHs possess adjustable metal ion composition, alterable interlayer structure, and excellent drug loading and delivery capabilities. 4

MicroRNAs (miRNAs) play a critical role in bone remodeling and hold promise as a novel approach to treating bone-related diseases. 5

Oleuropein (Ole) has shown chemo-preventive effects on various types of human tumors and may play a therapeutic role in the prevention and treatment of cancer-related bone diseases. 8

Astaxanthin, a pigment found in aquatic organisms, exhibits strong antioxidant activity and may play a role in counteracting skeletal injuries caused by oxidative stress. 10

Electrospun fibers offer a novel polymeric material for treating orthopedic diseases due to their three-dimensional structures, controlled drug-release responses, and high affinity with local tissues. 11

Mesoporous silica nanoparticles are promising carriers for the treatment of complex bone diseases such as bone cancer, bone infection, and osteoporosis. 12

Natural compounds targeting the RANKL signaling pathway are being investigated for their therapeutic effects on bone loss diseases like rheumatoid arthritis and osteoporosis. 13

Denosumab, a fully human monoclonal antibody against RANKL, shows potential in treating osteoporosis, rheumatoid arthritis, bone metastases, and multiple myeloma. 21

Bisphosphonates are medications that reduce bone resorption and are widely used for the prevention and treatment of osteoporosis. 22

Bisphosphonate-chemotherapeutic conjugates, such as MBC-11, show promising results in decreasing bone tumor burden, maintaining bone structure, and potentially increasing overall survival in tumor-induced bone disease (TIBD). 23

Treatment Summary

Lactoferrin, LDHs, miRNAs, oleuropein, astaxanthin, electrospun fibers, mesoporous silica nanoparticles, RANKL-targeted therapies, bisphosphonates, and MBC-11 are promising therapeutic approaches for various bone diseases. 3 4 5 8 10 11 12 13 21 22 23

Benefits and Risks

Benefits Summary

These treatments hold potential for improving bone health, reducing bone loss, promoting fracture repair, and managing bone-related diseases. 3 4 5 8 10 11 12 13 21 22 23

Risks Summary

All treatments carry risks, including potential side effects, allergic reactions, and drug interactions. 3 4 5 8 10 11 12 13 21 22 23

Comparison Between Studies

Commonalities

Many studies highlight the potential of lactoferrin, LDHs, miRNAs, oleuropein, astaxanthin, electrospun fibers, mesoporous silica nanoparticles, RANKL-targeted therapies, bisphosphonates, and MBC-11 as promising approaches for treating bone diseases. 3 4 5 8 10 11 12 13 21 22 23

Differences

These studies differ in their focus on specific diseases, treatment methods, and research designs. 3 4 5 8 10 11 12 13 21 22 23

Consistency and Discrepancies in Results

While promising results have emerged for various treatments of bone diseases, further research is needed to validate and optimize these approaches. 3 4 5 8 10 11 12 13 21 22 23

Considerations for Real-World Application

It is important to remember that treatment effectiveness can vary from person to person. It is crucial to consult with a healthcare professional for personalized advice and safe treatment. 3 4 5 8 10 11 12 13 21 22 23

Limitations of Current Research

Research on bone disease treatments is still in its early stages and requires further investigation. 3 4 5 8 10 11 12 13 21 22 23

Future Research Directions

Future research should focus on conducting larger clinical trials, comparing various treatment approaches, and investigating side effects and drug interactions. 3 4 5 8 10 11 12 13 21 22 23

Conclusion

Research on bone disease treatments has made significant progress in recent years, offering promising potential for improving the lives of patients. However, these treatments are not without risks. It is essential to consult with a healthcare professional for personalized advice and safe treatment. 3 4 5 8 10 11 12 13 21 22 23

Treatment List

Lactoferrin, LDHs, miRNAs, oleuropein, astaxanthin, electrospun fibers, mesoporous silica nanoparticles, RANKL-targeted therapies, bisphosphonates, MBC-11

Literature analysis of 24 papers
Positive Content
23
Neutral Content
0
Negative Content
1
Article Type
2
0
0
16
22
1.

Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group.

Author: HarrisS T, WattsN B, GenantH K, McKeeverC D, HangartnerT, KellerM, ChesnutC H, BrownJ, EriksenE F, HoseyniM S, AxelrodD W, MillerP D

Effective for osteoporosis
Increased bone density
Reduced fracture risk
Well tolerated

Risedronate therapy was effective and well-tolerated in treating postmenopausal women with established osteoporosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Algorithm for employing physical forces in metabolic bone diseases.

Author: MassariLeo

Improved quality of life
Reduced pain

This article emphasizes the importance of a multidisciplinary approach to metabolic bone diseases, specifically osteoporosis, highlighting the role of electrical field stimulation in treating vertebral fractures.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment.

Author: BianYixin, CaiXuejie, LvZehui, XuYiming, WangHan, TanChaoliang, LiangRuizheng, WengXisheng

Drug loading and delivery capabilities
Improved bone disease treatment
Bone diseases

This review summarizes the advancements of layered double hydroxides (LDHs) in treating bone diseases. LDHs offer adjustable properties and excellent drug delivery capabilities, making them promising materials for bone defects, infections, osteoarthritis, and tumors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Lipid Nanoparticles and Liposomes for Bone Diseases Treatment.

Author: BurdușelAlexandra-Cristina, AndronescuEcaterina

Bone regeneration
Drug delivery system
Treatment of bone diseases
Challenges in transport
Maintaining drug concentration
Storage limitations

Lipid nanoparticles and liposomes are widely used in drug delivery systems, offering advantages in biocompatibility, drug release control, and passive targeting. They show potential for treating bone diseases, but further research is needed to address limitations in transport, storage, and maintaining drug concentration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Novel Treatment Options in Childhood Bone Diseases.

Author: JazbinšekSončka, KoceMaša, KotnikPrimož

Etiology-based treatment
Improved bone density
Increased growth
Safety concerns

Novel treatments for childhood bone diseases, including denosumab for osteoporosis, burosumab for X-linked hypophosphatemic rickets, and vosoritide for achondroplasia (ACH), have shown promise.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Effects of oleuropein on tumor cell growth and bone remodelling: Potential clinical implications for the prevention and treatment of malignant bone diseases.

Author: LetoGaetano, FlandinaCarla, CrescimannoMarilena, GiammancoMarco, SepportaMaria Vittoria

Oleuropein bone disease prevention
Oleuropein cancer prevention

Oleuropein, a bioactive compound found in olive leaves, fruits, and oil, has shown promising chemo-preventive effects in various human tumors. This review explores the potential therapeutic role of oleuropein in preventing and treating cancer-related bone diseases by modulating key steps of malignant progression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Bone metabolism regulation: Implications for the treatment of bone diseases.

Author: YaoDanqi, HuangLianfang, KeJianhao, ZhangMing, XiaoQin, ZhuXiao

Bone disease treatment

The study investigated signaling pathways that affect bone metabolism, with the goal of improving the diagnosis and treatment of future clinical bone diseases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

A potential role for astaxanthin in the treatment of bone diseases (Review).

Author: ValentiMaria Teresa, PerducaMassimiliano, RomanelliMaria Grazia, MottesMonica, Dalle CarbonareLuca

Bone homeostasis
Skeletal injury treatment

Oxidative stress damages bone homeostasis by increasing reactive oxygen species and pro-resorption cytokines. Astaxanthin, a potent antioxidant, can help to counteract these effects and protect bone. This review explores the role of astaxanthin in counteracting oxidative stress-induced skeletal injuries.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Electrospun fibers: an innovative delivery method for the treatment of bone diseases.

Author: MaoYingji, ZhaoYupeng, GuanJingjing, GuanJianzhong, YeTingjun, ChenYu, ZhuYansong, ZhouPinghui, CuiWenguo

Orthopedic disease treatment

Drug-loaded electrospun fibers are a promising material for treating orthopedic injuries due to their 3-dimensional structure, controlled drug release, and high affinity with local tissues. They have potential applications in treating bone and cartilage defects, tendon adhesion, vascular remodeling, skin grafting, and nervous-system injuries.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Mesoporous Silica Nanoparticles for the Treatment of Complex Bone Diseases: Bone Cancer, Bone Infection and Osteoporosis.

Author: Gisbert-GarzaránMiguel, ManzanoMiguel, Vallet-RegíMaría

Bone disease treatment

This review explores the potential of silica-based mesoporous nanoparticles for treating bone diseases such as bone cancer, bone infection, and osteoporosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

The Study of Natural Compounds Targeting RANKL Signaling Pathway for the Treatment of Bone Diseases.

Author: LiuChang, HeYuan, XuXiaobing, HeLijun, HeBaorong, KongLingbo

Bone health
Bone loss

Bone loss diseases are a common problem, particularly for older adults. This study reviews current research on the role of RANKL in bone loss and the potential of natural compounds for treating these diseases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

[Pathological and metabolic bone diseases: Clinical importance for fracture treatment].

Author: OheimR

Fracture prevention
Hypocalcemia prevention

This review discusses the importance of considering underlying bone diseases when treating fractures, focusing on osteoporosis, osteopetrosis, hypophosphatasia, and Paget's disease of bone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

18.

[Guidelines on prevention and treatment of vitamin D deficiency. Italian Society for Osteoporosis, Mineral Metabolism and Bone Diseases (SIOMMMS)].

Author: AdamiS, RomagnoliE, CarnevaleV, ScillitaniA, GiustiA, RossiniM, GattiD, NutiR, MinisolaS,

Vitamin D deficiency prevention
Vitamin D status improvement
Vitamin D intoxication

Vitamin D deficiency is prevalent in Italy, especially among the elderly. The guidelines recommend daily vitamin D supplementation of 1,200-2,000 IU for those with no effective sun exposure.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Italian

21.

An antibody against RANKL for the treatment of osteoporosis, inflammatory and malignant bone diseases.

Author: Maldonado-GonzalesEduardo, PietschmannPeter

Bone metastases treatment
Multiple myeloma treatment
Osteoporosis treatment
Rheumatoid arthritis treatment

Denosumab, a fully human monoclonal antibody against RANKL, is being studied for the treatment of bone diseases. This review explores the potential role of denosumab in osteoporosis, rheumatoid arthritis, bone metastases, and multiple myeloma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

Bisphosphonates in the treatment of metabolic bone diseases.

Author: ArantesHenrique Pierotti, SilvaAndré Gonçalves da, Lazaretti-CastroMarise

Fracture prevention
Osteoporosis treatment
Jaw osteonecrosis

Osteoporosis is a bone disease characterized by low bone mass and microarchitectural deterioration, increasing fracture risk. Bisphosphonates are medications that reduce bone resorption by osteoclasts, improving the balance between resorption and formation. These medications are approved for both prevention and treatment of osteoporosis and can be administered orally or intravenously. Bisphosphonates are generally well-tolerated and safe with proper administration. Serious side effects, such as osteonecrosis of the jaw, are rare. Bisphosphonates are widely prescribed for osteoporosis management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

A promising approach for treatment of tumor-induced bone diseases: utilizing bisphosphonate derivatives of nucleoside antimetabolites.

Author: ReinholzMonica M, ZinnenShawn P, DueckAmylou C, DingliDavid, ReinholzGregory G, JonartLeslie A, KitzmannKathleen A, BruzekAmy K, NegronVivian, AbdallaAbdalla K, ArendtBonnie K, CroattAnthony J, Sanchez-PerezLuis, SebestaDavid P, LönnbergHarri, YonedaToshiyuki, NathKarl A, JelinekDiane F, RussellStephen J, IngleJames N, SpelsbergThomas C, DixonHenry B F Hal, KarpeiskyAlexander, LingleWilma L

Bone health
TIBD treatment

This study examined the effects of MBC-11, a bisphosphonate-chemotherapeutic conjugate, on tumor-induced bone disease (TIBD) in two mouse models. MBC-11 reduced bone tumor burden, maintained bone structure, and potentially increased overall survival, suggesting its potential as a treatment for TIBD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Molecular treatment strategies and surgical reconstruction for metastatic bone diseases.

Author: ZouXuenong, ZouLijin, HeYing, BüngerCody

Bone metastasis inhibition

Bone metastasis is a complex process that involves cancer cells and the bone microenvironment. Molecular therapies targeting these pathways could prevent or treat bone metastasis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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