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Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma.

Author: CarcabosoAngel M, DyerMichael A, EgorinMerrill, FedericoSara, NemethKatie M, SchaiquevichPaula, ShenYing, StewartClinton, ZhangJiakun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The combination of topotecan and carboplatin was effective in treating retinoblastoma in a xenograft model, but both drugs cause myelosuppression in children.
Paper Details　
Original Abstract of the Article :
The authors demonstrated previously that the combination of topotecan (TPT) and carboplatin (CBP) was more effective than current chemotherapeutic combinations used to treat retinoblastoma in an orthotopic xenograft model. However, systemic coadministration of these agents is not ideal, because both...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/20818652

データ提供：米国国立医学図書館（NLM）

Combating Retinoblastoma: A Novel Approach with Topotecan and Carboplatin

This research investigates the efficacy of a combined treatment strategy using topotecan and carboplatin against retinoblastoma, a rare eye cancer. The study utilizes a preclinical model to evaluate the potential of this drug combination to overcome the limitations of current therapies.

A Promising Combination for Retinoblastoma Treatment

The study highlights the effectiveness of combining topotecan and carboplatin against retinoblastoma in a preclinical setting. The combination demonstrates superior efficacy compared to existing therapies.

A Ray of Hope for Retinoblastoma

Imagine retinoblastoma as a stubborn desert sandstorm, resisting all attempts to be subdued. This research explores a novel approach to combating this challenging condition by combining two powerful anti-cancer drugs, topotecan and carboplatin. This study offers a ray of hope for better treatment options for retinoblastoma, a cancer that often affects young children.

Dr.Camel's Conclusion

This research provides compelling evidence for the efficacy of topotecan and carboplatin combination therapy against retinoblastoma in a preclinical setting. The findings offer a promising avenue for developing more effective treatment strategies for this challenging cancer.
Date :
  1. Date Completed 2011-03-15
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20818652

DOI: Digital Object Identifier

NIHMS224745

Related Literature

Article Analysis
・Side Effects of topotecan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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