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Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes: the PLATO (PLATelet inhibition and patient Outcomes) PLATELET substudy.

Author: AngiolilloDominick J, BeckerRichard C, CannonChristopher P, DesaiBhaloo, EcobRosemary, EmanuelssonHakan, HustedSteen, PatilShankar B, StoreyRobert F, WallentinLars

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Ticagrelor achieved greater antiplatelet effect than clopidogrel in patients with acute coronary syndromes, both during maintenance therapy and in the first hours of treatment.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: The PLATO (PLATelet inhibition and patient Outcomes) PLATELET substudy aimed to compare the antiplatelet effects of clopidogrel and ticagrelor in patients with acute coronary syndromes. BACKGROUND: The PLATO study demonstrated superiority of ticagrelor over clopidogrel in the prevention...See full text at original site
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引用元：
https://doi.org/10.1016/j.jacc.2010.03.100

データ提供：米国国立医学図書館（NLM）

Ticagrelor vs. Clopidogrel: Comparing Antiplatelet Effects in Acute Coronary Syndromes

This study compared the antiplatelet effects of ticagrelor and clopidogrel, two commonly used medications to prevent blood clots in patients with acute coronary syndromes (ACS). Using a randomized controlled trial, the study found that ticagrelor achieved greater suppression of platelet reactivity than clopidogrel, both in the first hours of treatment and during maintenance therapy. These findings suggest that ticagrelor may be a more effective antiplatelet agent for patients with ACS.

Ticagrelor: A Powerful Oasis in the Desert of Platelet Aggregation

This study examines the impact of two antiplatelet medications, ticagrelor and clopidogrel, on platelet aggregation in patients with acute coronary syndromes. The researchers found that ticagrelor achieved greater suppression of platelet aggregation than clopidogrel, providing a more effective solution for preventing blood clots in this high-risk population. The study highlights the importance of choosing the most effective antiplatelet agent for individual patients.

Minimizing the Risk of Blood Clots

This study emphasizes the importance of careful medication selection to minimize the risk of blood clots in patients with acute coronary syndromes. The findings suggest that ticagrelor may offer a more powerful and effective solution for preventing these potentially life-threatening complications.

Dr. Camel's Conclusion

This study provides valuable insights into the antiplatelet effects of ticagrelor and clopidogrel in patients with acute coronary syndromes. The results suggest that ticagrelor may be a more effective option for preventing blood clots and reducing the risk of ischemic events. However, it is crucial to consult with a healthcare professional to determine the best treatment plan for individual patients.

Date :
  1. Date Completed 2010-11-02
  2. Date Revised 2023-08-08
Further Info :

Pubmed ID

20832963

DOI: Digital Object Identifier

10.1016/j.jacc.2010.03.100

Related Literature

Article Analysis
・Effects of clopidogrel
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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