Paper Details

  1. Home
  2. Paper Details

Comparative efficacy and overall safety of different doses of consensus interferon for treatment of chronic HCV infection: a systematic review and meta-analysis.

Author: AlavianSeyed-Moayed, BehnavaBita, TabatabaeiSeyed Vahid

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

A higher dose of consensus interferon (CIFN) did not lead to a higher rate of sustained virological response (SVR) compared to a lower dose.
Paper Details　
Original Abstract of the Article :
BACKGROUND: About one-half of patients with hepatitis C genotype 1 and one-third with genotype 2/3 have treatment failure with peginterferon alpha and ribavirin. Consensus interferon (CIFN) is an option for retreatment of these patients. OBJECTIVE: To summarize comparative safety and efficacy of di...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s00228-010-0881-7

データ提供：米国国立医学図書館（NLM）

Comparative Efficacy and Overall Safety of Different Doses of Consensus Interferon for Treatment of Chronic HCV Infection: A Systematic Review and Meta-Analysis

This research delves into the complex world of hepatitis C treatment, focusing on the efficacy and safety of different doses of consensus interferon (CIFN) for patients with chronic hepatitis C infection. The authors conducted a comprehensive systematic review and meta-analysis of randomized clinical trials (RCTs) to assess the comparative efficacy and safety of various CIFN regimens. The study provides valuable insights into the optimal dosage and treatment duration of CIFN.

CIFN: A Valuable Tool for HCV Treatment, But Dosage Matters

The study found that a dose of 9 μg thrice weekly (tiw) was associated with a significantly higher rate of sustained virological response (SVR) compared to 3 μg. However, high daily induction dose regimens of CIFN did not yield a higher rate of SVR than low daily induction dose treatment regimens. It's like navigating a vast desert - you need to find the right path and the right amount of water to reach your destination (SVR) successfully.

Continued Research to Optimize Treatment

The study acknowledges the need for further research to optimize the duration and safety profile of CIFN therapy. The authors emphasize the need for more studies to address the limitations in current research and to provide more definitive conclusions regarding the optimal use of CIFN in treating chronic HCV infection.

Dr. Camel's Conclusion

This study sheds light on the importance of optimizing CIFN dosage for effective HCV treatment. The findings suggest that a dose of 9 μg tiw may be the most effective regimen, but further research is necessary to determine the optimal duration and safety profile of CIFN therapy. It's a journey through the desert of hepatitis C treatment, and we need to continue exploring the best routes to reach a successful outcome.

Date :
  1. Date Completed 2010-12-15
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20857094

DOI: Digital Object Identifier

10.1007/s00228-010-0881-7

Related Literature

Article Analysis
・Effective treatment of hepatitis c
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.