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Ca2+, Mg2+-dependent DNase involvement in apoptotic effects in spermatozoa of sea urchin Strongylocentrotus intermedius induced by two-headed sphingolipid rhizochalin.

Author: MakarievaTatyana N, MenzorovaNatalia I, RasskazovValeriy A, ShastinaValeria V, SibirtsevJuriy T

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study found that rhizochalin (Rhz), a two-headed sphingolipid, induced apoptosis in sea urchin spermatozoa. This process involved activation of caspase-3, which likely activated Ca(2+), Mg(2+)-dependent DNase (Ca, Mg-DNase), leading to internucleosomal DNA cleavage. This suggests that Ca, Mg-DNase plays a key role in the apoptotic process in sea urchin spermatozoa.
Paper Details　
Original Abstract of the Article :
Previously, we have purified three distinct DNases from spermatozoa of sea urchin Strongylocentrotus intermedius and we suppose the role of Ca(2+), Mg(2+)-dependent DNase (Ca, Mg-DNase) in apoptosis of spermatozoa. Two-headed sphingolipid rhizochalin (Rhz) induced characteristic apoptotic nuclear ch...See full text at original site
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引用元：
https://doi.org/10.1007/s10126-010-9324-9

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2011-12-06
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20938797

DOI: Digital Object Identifier

10.1007/s10126-010-9324-9

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Languages

English

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