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The effects of dose and timing of esomeprazole administration on 24-h, daytime and night-time acid inhibition in healthy volunteers.

Author: Bokelund SinghS, NagyP, RöhssK, SagarM, Wilder-SmithC

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A randomized, seven-way crossover study in healthy volunteers evaluated the pharmacodynamic effects of various esomeprazole dosage and timing regimens. Esomeprazole 20 mg twice daily provided superior acid inhibition compared to all once-daily regimens. Dosing before breakfast improved 24-h and daytime acid inhibition compared to other dosing times. Night-time acid inhibition was improved with esomeprazole 40 mg once daily administered before dinner or at bedtime.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Symptoms of gastro-oesophageal reflux disease (GERD) may persist despite daily treatment with a proton pump inhibitor (PPI). AIM: To compare the pharmacodynamic effect of various esomeprazole dosage and timing regimens in healthy volunteers. METHODS: The effect of different esomeprazol...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2036.2010.04469.x

データ提供：米国国立医学図書館（NLM）

Esomeprazole: Optimizing Dosage and Timing for Acid Inhibition

The quest for effective gastroesophageal reflux disease (GERD) treatment often involves fine-tuning medication regimens. This study investigates the pharmacodynamic effects of esomeprazole, a proton pump inhibitor, focusing on the impact of dosage and timing on acid inhibition. The researchers aimed to identify the most effective esomeprazole regimen for individual patients, like a camel seeking the perfect patch of oasis to quench its thirst.

The researchers conducted a seven-way crossover study involving healthy volunteers, comparing various dosage regimens of esomeprazole administered at different times of day. They found that esomeprazole 20 mg twice daily (b.d.) provided superior acid inhibition compared to all 20 mg and 40 mg once daily (od) regimens. However, esomeprazole 40 mg b.d. outperformed esomeprazole 20 mg b.d. They also observed that esomeprazole administered before breakfast resulted in better 24-hour and daytime acid inhibition compared to administration before dinner or bedtime.

Optimizing Esomeprazole Regimen for GERD

This study demonstrates the importance of customizing esomeprazole regimens based on individual patient needs, considering both dosage and timing for effective acid inhibition.

A Camel's Perspective on GERD Management

As a camel, I’ve learned to adapt to the desert environment, adjusting my water intake and movement patterns to survive the harsh conditions. This study reminds us that effective GERD management often involves a similar approach, tailoring medication regimens to individual needs.

Dr.Camel's Conclusion

This study emphasizes the importance of optimizing esomeprazole regimens for GERD, taking into consideration both dosage and timing for effective acid inhibition. The findings offer valuable insights for clinicians seeking to personalize treatment strategies for individual patients.

Date :
  1. Date Completed 2011-02-24
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

20955444

DOI: Digital Object Identifier

10.1111/j.1365-2036.2010.04469.x

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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