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N-methyl-D-aspartate receptor-mediated modulations of the anti-allodynic effects of 5-HT1B/1D receptor stimulation in a rat model of trigeminal neuropathic pain.
Author: BourgoinSylvie, HamonMichel, KayserValérie, LatrémolièreAlban
Original Abstract of the Article :
Previous studies showed that triptans and other 5-HT(1B/1D)-receptor agonists attenuate hyper-responsiveness to mechanical stimulation of the face in a rat model of trigeminal neuropathic pain, probably by activating 5-HT(1B/1D)-receptors on primary afferent nociceptive fibers. We now tested whether...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://doi.org/10.1016/j.ejpain.2010.09.012
データ提供:米国国立医学図書館(NLM)
Targeting Trigeminal Neuropathic Pain: A Novel Approach
Imagine a desert, where a gentle breeze can transform into a sandstorm in an instant. This research explores a novel approach to managing trigeminal neuropathic pain, a condition characterized by chronic pain in the face.
Modulating the Anti-Allodynic Effects of 5-HT1B/1D Receptor Stimulation
The study focuses on the potential of combining 5-HT1B/1D receptor agonists, drugs that target certain serotonin receptors, with NMDA receptor antagonists, drugs that block the activity of NMDA receptors. This combination approach could potentially enhance the pain-relieving effects of 5-HT1B/1D receptor agonists.
Promising Results for Trigeminal Neuropathic Pain
The researchers found that blocking NMDA receptors significantly potentiated the anti-allodynic effects of 5-HT1B/1D receptor agonists in a rat model of trigeminal neuropathic pain. This finding suggests that combining these two types of drugs could be a promising approach for treating this challenging condition.
Dr. Camel's Conclusion
This research offers a glimmer of hope for patients suffering from trigeminal neuropathic pain. By combining different drug classes, we might be able to control this unpredictable pain, just as a desert traveler uses various strategies to navigate changing weather conditions.
Date :
- Date Completed 2011-09-15
- Date Revised 2022-04-08
Further Info :
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