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Effects of CYP2C19 genotype on outcomes of clopidogrel treatment.

Author: AnandSonia S, BhattDeepak L, ConnollyStuart J, EikelboomJohn W, FoxKeith A A, HirshJack, MehtaShamir R, ParéGuillaume, SimonsenKaty, YusufSalim

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effect of CYP2C19 genotype on the effectiveness of clopidogrel. The effect of clopidogrel in reducing cardiovascular events was similar in patients with and without loss-of-function CYP2C19 alleles. Gain-of-function carriers derived more benefit from clopidogrel than noncarriers.
Paper Details　
Original Abstract of the Article :
BACKGROUND: It has been suggested that clopidogrel may be less effective in reducing the rate of cardiovascular events among persons who are carriers of loss-of-function CYP2C19 alleles that are associated with reduced conversion of clopidogrel to its active metabolite. METHODS: We genotyped patien...See full text at original site
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引用元：
https://doi.org/10.1056/NEJMoa1008410

データ提供：米国国立医学図書館（NLM）

CYP2C19 Genotype and Clopidogrel Treatment Outcomes

Clopidogrel, a commonly used antiplatelet medication, is crucial for preventing cardiovascular events. However, the effectiveness of clopidogrel can vary depending on individual genetic factors. This study investigates the impact of CYP2C19 genotype, a gene that plays a role in drug metabolism, on the outcomes of clopidogrel treatment. Researchers analyzed data from two large randomized trials to assess the association between CYP2C19 genotype and the efficacy and safety of clopidogrel.

Personalized Medicine: Tailoring Clopidogrel Treatment

The study found that the effectiveness of clopidogrel was consistent across different CYP2C19 genotypes, suggesting that genetic variations in CYP2C19 do not significantly influence the efficacy of clopidogrel in preventing cardiovascular events. However, the study observed a potential interaction between CYP2C19 genotype and the risk of bleeding, suggesting that individuals with certain genotypes may be at higher risk of bleeding complications.

Understanding Individual Variations in Drug Response

This research highlights the growing importance of personalized medicine, where treatment strategies are tailored to individual genetic factors. By understanding the influence of genes on drug metabolism, we can optimize treatment outcomes and minimize potential adverse effects. It's like adapting to the unique characteristics of a desert landscape – recognizing the differences in terrain allows us to choose the most appropriate path for our journey.

Dr.Camel's Conclusion

This study underscores the importance of considering individual genetic factors when prescribing medications, particularly those that undergo extensive metabolism. By embracing the principles of personalized medicine, we can enhance treatment efficacy and ensure the safety of our patients. Just as a desert traveler must be mindful of the terrain to navigate safely, healthcare providers must be aware of individual variations in drug response to provide optimal care.

Date :
  1. Date Completed 2010-11-05
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20979470

DOI: Digital Object Identifier

10.1056/NEJMoa1008410

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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