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Synergistic effects of parthenolide and benznidazole on Trypanosoma cruzi.

Author: Dias FilhoBenedito Prado, IzumiErika, NakamuraCelso Vataru, Pelizzaro-RochaKarin Juliane, TiumanTatiana Shioji, Ueda-NakamuraTânia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the in vitro combinatory effect of parthenolide and benznidazole against Trypanosoma cruzi. Parthenolide showed synergistic activity against epimastigote forms, reducing the required concentration of benznidazole.
Paper Details　
Original Abstract of the Article :
Parthenolide previously isolated from Tanacetum vulgare was tested for its in vitro combinatory effect with benznidazole against Trypanosoma cruzi. Parthenolide showed a strong synergistic activity against epimastigote forms, reducing 23-fold the concentration of benznidazole necessary to inhibit 50...See full text at original site
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引用元：
https://doi.org/10.1016/j.phymed.2010.09.005

データ提供：米国国立医学図書館（NLM）

A Powerful Duo: Parthenolide and Benznidazole against Trypanosoma cruzi

The researchers embark on a fascinating quest to combat the parasitic infection caused by Trypanosoma cruzi, the culprit behind Chagas disease. The study focuses on the synergistic effects of two promising compounds: parthenolide, derived from the common tansy plant, and benznidazole, a current treatment for Chagas disease. They seek to determine if these drugs, when combined, can enhance the fight against this debilitating infection.

Synergistic Action Against Chagas Disease

The study demonstrates the synergistic potential of parthenolide and benznidazole, highlighting a significant reduction in the concentration of benznidazole needed to inhibit the parasite's growth when combined with parthenolide. These findings suggest a powerful new weapon in the arsenal against Chagas disease, offering hope for more effective treatments.

Understanding Chagas Disease

Chagas disease is a serious and often neglected parasitic infection that affects millions worldwide. It can lead to heart failure, digestive problems, and other complications. Early diagnosis and treatment are crucial for preventing the development of severe symptoms. This study emphasizes the importance of ongoing research and development of effective therapies for Chagas disease.

Dr.Camel's Conclusion

This study offers a glimmer of hope in the fight against Chagas disease. The synergistic effects of parthenolide and benznidazole highlight the potential for more effective treatments. Further research is needed to explore the full therapeutic potential of this combination and determine its safety and efficacy in clinical settings.

Date :
  1. Date Completed 2011-05-24
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

21035317

DOI: Digital Object Identifier

10.1016/j.phymed.2010.09.005

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Languages

English

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