Plasma cannabinoid pharmacokinetics following controlled oral delta9-tetrahydrocannabinol and oromucosal cannabis extract administration.

Author: DarwinW David, GoodwinRobert S, HuestisMarilyn A, KarschnerErin L, WrightStephen

Paper Details 
Original Abstract of the Article :
Sativex(®), a cannabis extract oromucosal spray containing Δ(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD), is currently in phase III trials as an adjunct to opioids for cancer pain treatment, and recently received United Kingdom approval for treatment of spasticity. There are indications that...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/21078841

データ提供:米国国立医学図書館(NLM)

Unveiling the Secrets of Cannabinoid Pharmacokinetics

The realm of pharmacology is a vast desert, filled with intricate pathways and complex interactions. This particular research delves into the intricate world of cannabinoid pharmacokinetics, specifically focusing on the interaction between delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD). The study employed a controlled oral administration of THC and oromucosal cannabis extract to investigate the impact of these cannabinoids on the body. The researchers discovered a potential modulation of THC's effects by CBD, highlighting the complex interplay between these two cannabinoids.

The Potential Impact of CBD on THC

The findings suggest that CBD might influence the pharmacokinetic profile of THC, ultimately affecting its therapeutic efficacy. This dynamic interaction between CBD and THC could have profound implications for the development of cannabis-based medications, particularly for conditions like cancer pain treatment and spasticity.

Navigating the Shifting Sands of Cannabinoid Research

Understanding the nuances of cannabinoid interactions is crucial for maximizing therapeutic benefits while minimizing potential risks. This research serves as a beacon, guiding us through the ever-shifting sands of cannabinoid research. As we continue to explore the therapeutic potential of cannabis, this study emphasizes the importance of carefully considering the complex interactions between various cannabinoids.

Dr.Camel's Conclusion

This research sheds light on the intricate dance between THC and CBD, reminding us that the desert of pharmacological knowledge is vast and requires careful exploration to uncover the secrets of therapeutic efficacy. The potential modulation of THC by CBD opens new avenues for research and development of safer and more effective cannabis-based medications.

Date :
  1. Date Completed 2011-01-20
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

21078841

DOI: Digital Object Identifier

NIHMS486958

Related Literature

SNS
PICO Info
in preparation
Languages

English

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