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Toxicology and safety of COMT inhibitors.

Author: HaasioKristiina

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Catechol-O-methyltransferase (COMT) inhibitors are used to treat Parkinson's disease, but some have been associated with toxic effects, particularly liver toxicity. This review discusses the development, safety, and effectiveness of COMT inhibitors.
Paper Details　
Original Abstract of the Article :
The development of catechol-O-methyltransferase (COMT) inhibitors for the adjunct treatment to levodopa and aromatic L-amino acid decarboxylase (AADC) inhibitors in Parkinson's disease started in the late 1950s. The first-generation inhibitors were associated with toxic properties: they induced conv...See full text at original site
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引用元：
https://doi.org/10.1016/B978-0-12-381326-8.00007-7

データ提供：米国国立医学図書館（NLM）

COMT Inhibitors: Managing Parkinson's Disease

Parkinson's disease, a neurodegenerative disorder, affects millions worldwide. It's like a camel navigating a desert, where the path becomes increasingly difficult to traverse. This study examines the toxicology and safety of catechol-O-methyltransferase (COMT) inhibitors, which are used to treat Parkinson's disease.

COMT Inhibitors: A Desert Oasis in Parkinson's Treatment

The authors discuss the development of COMT inhibitors and their role in treating Parkinson's disease. They highlight the effectiveness of entacapone and tolcapone, noting their potential side effects. Imagine a camel finding an oasis in the desert, offering relief but also potential dangers if not approached with caution. This research is like exploring the potential benefits and risks associated with COMT inhibitors in treating Parkinson's disease.

Navigating the Terrain: A Balance of Risks and Benefits

The findings of this study emphasize the need for careful monitoring and management of COMT inhibitors. Just as a camel carefully evaluates its surroundings before seeking refuge in an oasis, we must weigh the potential benefits and risks of different treatments.

Dr. Camel's Conclusion

This study provides valuable insights into the use of COMT inhibitors in managing Parkinson's disease. It highlights the importance of balancing potential benefits and risks in medical treatment. Just as a camel navigates the desert with a blend of caution and determination, we can approach Parkinson's disease with a comprehensive understanding of available treatments and their potential impact.
Date :
  1. Date Completed 2011-03-07
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

21095462

DOI: Digital Object Identifier

10.1016/B978-0-12-381326-8.00007-7

SNS
PICO Info
in preparation
Languages

English

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