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Effectiveness of conventional, low-dose and intermittent oral isotretinoin in the treatment of acne: a randomized, controlled comparative study.

Author: HanT Y, HongC K, LeeJ W, LiK, ParkK Y, SeoS J, YooK H

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The effectiveness of standard isotretinoin treatment for acne is well known, but recent studies have explored the use of lower doses and intermittent treatment. However, there is currently no research directly comparing these three treatment approaches.
Paper Details　
Original Abstract of the Article :
The efficacy of conventional isotretinoin treatment (0·5-1·0 mg kg⁻¹ daily for 16-32 weeks, reaching a cumulative dose of 120 mg kg⁻¹) for acne has been well established. To date, there are many reports regarding the efficacy of low-dose and intermittent isotretinoin treatment in patients with acne....See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2133.2010.10152.x

データ提供：米国国立医学図書館（NLM）

Isotretinoin for Acne: Exploring Different Dosage Regimens

Acne can be a frustrating and persistent skin condition, as persistent as a desert mirage. This study investigates the effectiveness of different dosage regimens of isotretinoin, a powerful medication used to treat severe acne.

The study compares three different regimens: conventional high-dose, low-dose, and intermittent isotretinoin therapy. The study found that all three regimens were effective in reducing acne lesions, with conventional high-dose therapy achieving the most significant improvement. However, low-dose and intermittent therapy were associated with fewer side effects.

Tailoring Treatment for Acne

This study highlights the importance of tailoring isotretinoin therapy to individual patients' needs. It suggests that low-dose and intermittent therapy may be a viable option for patients who are concerned about side effects or who require a more flexible treatment approach. This research underscores the importance of patient-centered care, considering individual preferences and risk factors in developing treatment plans.

A Multi-pronged Approach to Acne

This research underscores the importance of a multi-pronged approach to treating acne. While isotretinoin therapy is a powerful tool, it is often used in combination with other treatments, such as topical medications and lifestyle modifications, to achieve the best results. This research emphasizes the importance of a comprehensive approach to skin health, considering the interplay of internal and external factors.

Dr. Camel's Conclusion

This study on isotretinoin therapy for acne offers valuable insights into the effectiveness of different dosage regimens. It highlights the importance of tailoring treatment to individual patient needs and considering the balance between efficacy and side effects. This research underscores the importance of a multi-pronged approach to treating acne, combining medication, lifestyle modifications, and other supportive therapies to achieve the best possible outcomes.

Date :
  1. Date Completed 2012-01-20
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

21114478

DOI: Digital Object Identifier

10.1111/j.1365-2133.2010.10152.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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