Paper Details

  1. Home
  2. Paper Details

Response-guided induction therapy in pediatric acute myeloid leukemia with excellent remission rate.

Author: AbrahamssonJonas, ForestierErik, HasleHenrik, HeldrupJesper, JahnukainenKirsi, JónssonOlafur G, LausenBirgitte, PalleJosefine, ZellerBernward

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A response-guided induction strategy including idarubicin was effective in treating children with acute myeloid leukemia (AML). In a study of 151 Nordic children with AML, the overall remission frequency was 97.4%, with a low induction death rate of 1.3%.
Paper Details　
Original Abstract of the Article :
PURPOSE: To evaluate the early treatment response in children with acute myeloid leukemia (AML) using a response-guided induction strategy that includes idarubicin in the first course. PATIENTS AND METHODS: All Nordic children with AML younger than 15 years (n = 151) were treated on the Nordic Soci...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1200/JCO.2010.30.6829

データ提供：米国国立医学図書館（NLM）

Response-Guided Induction Therapy for Pediatric Acute Myeloid Leukemia

Navigating the treacherous terrain of childhood cancer treatment requires careful consideration and a keen eye for detail. This study focuses on a response-guided induction strategy for pediatric acute myeloid leukemia (AML), a type of cancer that affects the blood and bone marrow. The researchers sought to find the best approach to this challenging disease, much like a camel navigating a winding path through a sandstorm.

Tailoring Treatment for Better Outcomes

The authors of this study employed a strategy known as response-guided induction therapy. This approach involves monitoring the patient's response to treatment and adjusting the therapy accordingly. The researchers evaluated the success of this strategy in a group of 151 children with AML. Their results demonstrated that this individualized approach led to an excellent remission rate, with 97.4% of patients achieving remission. This is a significant advancement in the fight against childhood leukemia, akin to discovering a hidden oasis in the desert, offering a safe haven from the harsh conditions.

A Promising Path for Childhood Cancer Treatment

The findings suggest that response-guided induction therapy may be a valuable tool in treating pediatric AML. This approach allows doctors to tailor treatment to the individual needs of the patient, leading to better outcomes and potentially reducing the side effects of chemotherapy. This is like finding the most suitable path through the desert for a caravan, ensuring a safe and successful journey.

Dr. Camel's Conclusion

This study highlights the importance of personalized medicine, particularly in the treatment of childhood cancers. By carefully monitoring patient responses and adjusting therapy accordingly, doctors can improve treatment outcomes and minimize the long-term effects of cancer treatment. This research is a beacon of hope in the fight against childhood AML, a testament to the power of science and the unwavering commitment to improving the lives of children.
Date :
  1. Date Completed 2011-02-22
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

21149663

DOI: Digital Object Identifier

10.1200/JCO.2010.30.6829

Related Literature

Article Analysis
・Side Effects of idarubicin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.