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The role of glucagon-like peptide-2 on apoptosis, cell proliferation, and oxidant-antioxidant system at a mouse model of intestinal injury induced by tumor necrosis factor-alpha/actinomycin D.

Author: Arda-PirincciPelin, BolkentSehnaz

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

GLP-2 was found to have protective, antiapoptotic, proliferative, and antioxidant effects against TNF-α/Act D-induced intestinal injury in a mouse model. GLP-2 pretreatment significantly reduced intestinal injury, apoptosis, and oxidative stress while increasing cell proliferation. This suggests that GLP-2 may be a potential therapeutic agent for TNF-α-mediated intestinal disorders.
Paper Details　
Original Abstract of the Article :
Tumor necrosis factor-alpha (TNF-α) is a multifunctional cytokine, which has the ability to produce cytotoxicity via induction of cell death and cell cycle arrest. Blocking the synthesis of protective proteins through a transcriptional inhibitor such as actinomycin D (Act D) sensitizes many cell typ...See full text at original site
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引用元：
https://doi.org/10.1007/s11010-010-0678-0

データ提供：米国国立医学図書館（NLM）

Glucagon-Like Peptide-2: Protecting the Intestines from TNF-α/Act D-Induced Injury

This study investigates the protective effects of glucagon-like peptide-2 (GLP-2) on intestinal injury induced by tumor necrosis factor-alpha (TNF-α) and actinomycin D (Act D) in mice. Imagine a camel caravan traversing a desert with harsh conditions, where TNF-α/Act D represents a dangerous sandstorm that threatens to damage the camels' delicate intestines. GLP-2 acts like a protective shield, helping to mitigate the harmful effects.

The study found that GLP-2 pretreatment prevented TNF-α/Act D-induced oxidative injury, reducing apoptosis, lipid peroxidation, and promoting cell proliferation. This means that GLP-2 helped protect the intestines from damage and promoted their recovery. It's like the camel caravan leader using a combination of strategies to protect the camels from the sandstorm, such as seeking shelter, using protective gear, and providing immediate medical attention.

GLP-2: A Potential Treatment for Intestinal Disorders

This research suggests that GLP-2 could be a potential therapeutic agent for TNF-α-mediated intestinal disorders. It's like a camel caravan having a versatile resource available to address different challenges encountered during their journey.

Protecting the Intestines: A Key to Health

This study highlights the importance of protecting the intestines, which play a crucial role in digestion and overall health. It's like understanding the importance of each camel in the caravan, with a healthy digestive system being essential for the entire caravan's well-being.

Dr. Camel's Conclusion

This study provides promising evidence for the protective effects of GLP-2 against intestinal injury. It's a reminder that ongoing research into novel therapeutic agents can lead to significant advancements in treating complex diseases.

Date :
  1. Date Completed 2011-07-15
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21153865

DOI: Digital Object Identifier

10.1007/s11010-010-0678-0

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English

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