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Hyperfractionated or accelerated radiotherapy for head and neck cancer.

Author: , AndrzejHliniak, AngKian K, BaujatBertrand, BernierJacques, BlanchardPierre, BourhisJean, BourredjemAbderrahmane, DobrowskyWerner, FallaiCarlo, FuKaren K, HayJohn H, HoriotJean Claude, Le MaîtreAurélie, MaillardEmilie, O'SullivanBrian, OvergaardJens, PajakThomas F, PignonJean Pierre, PintoLuiz Hj, PoulsenMichael G, SaundersMichelle, SkladowskiKrzystof, SylvesterRichard

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Altered fractionation radiotherapy improved survival in patients with head and neck squamous cell carcinoma. In a meta-analysis of 15 trials involving 6515 patients, altered fractionation radiotherapy was associated with a 3.4% absolute benefit in five-year survival. Hyperfractionated radiotherapy was found to be the most beneficial, with an 8% improvement in five-year survival.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Several trials have studied the role of altered fractionation radiotherapy in head and neck squamous cell carcinoma, but the effect of such treatment on survival is not clear. OBJECTIVES: The aim of this individual patient data (IPD) meta-analysis was to assess whether this type of radi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407183/

データ提供：米国国立医学図書館（NLM）

Altered Fractionation Radiotherapy: A Promising Approach for Head and Neck Cancer

This study, a comprehensive meta-analysis of individual patient data, investigates the potential of altered fractionation radiotherapy as a treatment for head and neck squamous cell carcinoma. The researchers analyzed data from 15 randomized controlled trials to evaluate the efficacy of this approach in improving survival and controlling tumor growth. Their findings offer valuable insights into the nuances of this complex treatment strategy.

Hyperfractionation Shows Superior Outcomes

The study revealed a significant survival benefit associated with altered fractionation radiotherapy, particularly hyperfractionation, compared to conventional radiotherapy. The analysis indicated a 3.4% absolute benefit at five years, with hyperfractionation exhibiting a more pronounced effect than accelerated radiotherapy. This suggests that the timing and frequency of radiation delivery can significantly impact treatment effectiveness.

Navigating the Desert of Cancer Treatment

This research, like a map guiding travelers through a vast desert, offers valuable insights into the potential of altering radiation treatment schedules to improve outcomes for patients with head and neck cancer. The findings highlight the importance of tailoring treatments to individual needs and exploring alternative approaches to maximize effectiveness and minimize side effects. It's a reminder that, just as the desert landscape changes with each storm, so too does our understanding of cancer treatment evolve with ongoing research.

Dr.Camel's Conclusion

Cancer treatment is a complex journey, like traversing a vast desert. This research, like a refreshing oasis, offers hope and new directions. Altered fractionation radiotherapy, particularly hyperfractionation, has emerged as a promising approach to improve survival and tumor control in patients with head and neck cancer. This study emphasizes the importance of ongoing research and the need to adapt treatments to individual patient needs. By delving deeper into these nuances, we can continue to find new ways to conquer this challenging disease.

Date :
  1. Date Completed 2011-02-10
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

21154350

DOI: Digital Object Identifier

PMC8407183

Related Literature

Article Analysis
・Effective treatment of head and neck cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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