Rituximab in Hodgkin lymphoma: is the target always a hit?

Author: AzimHatem A, CocorocchioEmilia, PeccatoriFedro A, PruneriGiancarlo, RavielePaola Rafaniello, SainiKamal S, SainiMonika Lamba, VanazziAnna

Paper Details 
Original Abstract of the Article :
In 1997, the anti-CD20 monoclonal antibody (MAb) rituximab became the first MAb approved for clinical use in oncology, and ushered in a new era of rationally designed targeted agents in cancer therapeutics. It is currently approved for use in non-Hodgkin lymphoma (NHL), chronic lymphoid leukemia (CL...See full text at original site
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引用元:
https://doi.org/10.1016/j.ctrv.2010.11.005

データ提供:米国国立医学図書館(NLM)

Rituximab in Hodgkin Lymphoma: A Targeted Approach

This study takes us into the world of cancer treatment, exploring the use of rituximab, a monoclonal antibody targeting CD20, for the treatment of Hodgkin lymphoma (HL). The researchers examined the rationale for using rituximab in HL, a complex decision akin to navigating a maze in the desert.

A strategic approach: Rituximab and Hodgkin lymphoma

The study explores the potential benefits and considerations of using rituximab in HL, especially for the lymphocyte predominant subtype where CD20 is frequently expressed. The researchers reviewed existing evidence and presented their experience treating patients with LPHL using rituximab. They concluded that rituximab can be a valuable addition to the treatment arsenal for specific HL subtypes, a targeted approach as precise as a camel's keen sense of direction.

A changing landscape: Hodgkin lymphoma treatment

This research highlights the evolving landscape of HL treatment. It suggests that targeted therapies, like rituximab, can play a significant role in improving outcomes for patients with specific HL subtypes. This approach, like a caravan navigating a shifting desert landscape, adapts to the unique characteristics of each patient and offers a promising path towards improved treatment.

Dr.Camel's Conclusion

This study provides a valuable overview of the use of rituximab in HL, a complex and evolving field of medicine. It emphasizes the importance of a personalized approach to cancer treatment, taking into account the specific characteristics of each patient and the availability of targeted therapies. This research underscores the importance of ongoing research and innovation in developing more effective and targeted treatments for cancer.

Date :
  1. Date Completed 2011-08-05
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

21183282

DOI: Digital Object Identifier

10.1016/j.ctrv.2010.11.005

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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