Pharmacokinetics and tolerability of intravenous cefotetan disodium for injection in healthy Chinese volunteers: A randomized, open-label, single- and multiple-dose study.

Author: ChenHui, LiZhongfang, LiuYani, LvYongning, ShiShaojun, ZhengHeng

Paper Details 
Original Abstract of the Article :
Cefotetan disodium for injection is a semisynthetic cephamycin antibiotic that exerts its bactericidal effects by inhibition of cell-wall synthesis. Despite being widely used in the treatment of various infections, little information is available on the pharmacokinetic properties of cefotetan disodi...See full text at original site
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引用元:
https://doi.org/10.1016/j.clinthera.2010.09.015

データ提供:米国国立医学図書館(NLM)

Unveiling the Pharmacokinetic Profile of Cefotetan Disodium in Chinese Subjects

The world of [Pharmacology] is constantly seeking to understand how medications behave within the human body. This study investigates the [pharmacokinetic properties] of cefotetan disodium for injection, a commonly used antibiotic, in Chinese volunteers. The researchers conducted a [randomized, open-label, single- and multiple-dose study] to shed light on how this medication is absorbed, distributed, metabolized, and eliminated in the body. This research is particularly valuable because [limited data] exists regarding the pharmacokinetic profile of cefotetan disodium in Chinese individuals, a population known to exhibit [unique metabolic characteristics].

Filling the Gaps in Pharmacokinetic Understanding

This research is crucial for ensuring [optimal dosing and treatment efficacy] of cefotetan disodium in Chinese patients. Understanding the [drug's behavior] within the body allows healthcare providers to [make informed decisions] about medication dosage and treatment duration. This research serves as a vital step in [personalizing medicine] for Chinese patients, allowing them to receive the best possible care.

A Step Toward Personalized Medicine

This study's focus on [population-specific pharmacokinetics] highlights the growing importance of [personalized medicine]. Like a skilled navigator charting a course across a vast desert, researchers are constantly seeking to understand the individual differences in drug responses, ensuring the most effective treatment for each patient.

Dr.Camel's Conclusion

This study serves as a reminder that the world of medicine is complex and diverse. What works for one person may not work for another, even if they share the same diagnosis. This study emphasizes the importance of understanding the unique characteristics of different populations, paving the way for more personalized and effective treatments.

Date :
  1. Date Completed 2011-04-25
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

21194607

DOI: Digital Object Identifier

10.1016/j.clinthera.2010.09.015

Related Literature

SNS
PICO Info
in preparation
Languages

English

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