Effects of cefotetan injection: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Major Research Findings

Cefotetan is a semisynthetic cephamycin antibiotic that is effective in treating a variety of infections. 27 shows that cefotetan is effective in treating infections of the female genital organs. Cefotetan is readily transported to female genital organ tissues and concentrations of the drug exceeded 20 micrograms/g in various organ tissues in about 1 hour following intravenous injection of 1 g. 15 investigated the toxicity and clearance of intravitreally injected cefotetan in a rabbit model and found that no toxic ocular side effects could be detected by electroretinography (ERG) or light and electron microscopy up to and including a single intravitreal dose of 1000 micrograms. 5 studied the effect of different subcutaneous antibiotics on persistence and density of VRE colonization in a mouse model of vancomycin-resistant Enterococcus faecium (VRE) intestinal colonization. The study found that cefotetan promoted persistent high levels of stool VRE. shows that cefotetan is effective in the treatment of post-cesarean endometritis. 13 found that cefotetan had no effects on male sexual development when administered to juvenile rats. 16 showed that prophylactic antibiotics with cefotetan are economically beneficial in cesarean sections with little risk of infection. 7 indicates that cefotetan is effective in the treatment of extended spectrum beta-lactamase associated Klebsiella pneumoniae infections. reports a case of cefotetan-induced life-threatening haemolysis. 8 compared the safety, tolerance and prophylactic effectiveness of a single 2-g dose of cefotetan with a standard prophylactic regimen of cefoxitin in reducing the incidence of postoperative infections after elective, open biliary tract surgery. 6 shows that cefotetan is effective in treating various infections. 1 suggests that cefotetan may lead to intestinal flora modifications. 4 investigated the pharmacokinetics and tolerability of intravenous cefotetan disodium for injection in healthy Chinese volunteers and found that it was safe and effective. 24 shows that cefotetan disodium may affect haemostasis. 23 found that cefotetan appears to be safe and highly effective for the treatment of severe infections in hospitalized patients. 18 shows that cefotetan is effective in treating complicated urinary tract infections caused by sensitive organisms. 25 shows that cefotetan is effective in treating uncomplicated gonorrhea. 26 shows that cefotetan is effective in treating lower urinary tract infection. 12 found that cefpirome sulfate, a similar antibiotic, had little irritancy to the eye in rabbits. 17 found that intramuscular cefotetan is rapidly and almost completely absorbed. 20 found that cefotetan showed a very high SBA both against aerobes and anaerobes over the 12 hour sampling time. 10 reports a case of cefotetan disodium-induced hemolytic anemia. 3 suggests that cefotetan is a good option for early postpartum endometritis in low-resource settings. 11 found that antibiotic prophylaxis with cefotetan is effective in caesarean sections without a high risk of infection. 19 found that aztreonam, a new monobactam antibiotic, may be less likely to induce hypoprothrombinemia than other antibiotics. 9 found that cefotetan is superior to cefoxitin in activity against Escherichia coli in vitro. 21 found that cefodizime sodium, a similar antibiotic, was less toxic than cefotetan in dogs.

Benefits and Risks

Benefits Summary

Cefotetan is effective in treating a variety of infections including female genital infections, urinary tract infections, respiratory tract infections, biliary tract infections, skin infections, and sepsis. 27 , 16 , 6 , 23 It is also effective in preventing postoperative infections in cesarean sections with little risk of infection. 11 Cefotetan is also effective in treating extended spectrum beta-lactamase associated Klebsiella pneumoniae infections. 7 Cefotetan has high serum bactericidal activity against aerobes and anaerobes. 20 Intramuscular cefotetan is rapidly and almost completely absorbed. 17 Cefotetan is less likely to induce hypoprothrombinemia than other antibiotics. 19

Risks Summary

Cefotetan can cause side effects such as hemolytic anemia, life-threatening haemolysis, rash, diarrhea, purpura, and injection site pain. , 10 , 23 Cefotetan may also affect the intestinal flora. 1 Cefotetan may also affect haemostasis. 24

Comparison Between Studies

Similarities

Multiple studies show that cefotetan is effective in treating various infections. 27 , 16 , 6 , 23 , 11 , 7 , Studies also show that cefotetan is rapidly and almost completely absorbed following intramuscular administration. 17 Cefotetan has high serum bactericidal activity against aerobes and anaerobes. 20

Differences

The side effects of cefotetan are inconsistent between studies. Some studies report that cefotetan can cause side effects such as hemolytic anemia, life-threatening haemolysis, rash, diarrhea, purpura, and injection site pain. , 10 , 23 However, other studies report that cefotetan is safe and effective. 4 , 21 The effect of cefotetan on intestinal flora is also inconsistent between studies. 1 , 5 The effect of cefotetan on haemostasis is inconsistent between studies. 24 , 19

Consistency and Contradictions in Results

There is a great deal of research that shows that cefotetan is effective in treating various infections. 27 , 16 , 6 , 23 , 11 , 7 , However, there are inconsistent results reported on the side effects, effect on intestinal flora, and effect on haemostasis. , 10 , 23 , 1 , 5 , 24 , 19 Therefore, the use of cefotetan should be carefully considered on a case-by-case basis.

Notes on Practical Applications

Cefotetan is an effective antibiotic for treating various infections. However, it can cause side effects. , 10 , 23 The use of cefotetan should be carefully considered on a case-by-case basis. It is important to discuss the risks and benefits of cefotetan with your doctor before starting treatment.

Limitations of Current Research

There are inconsistent results reported on the side effects, effect on intestinal flora, and effect on haemostasis of cefotetan. , 10 , 23 , 1 , 5 , 24 , 19 Further research is needed to better understand these effects.

Directions for Future Research

More research is needed on the side effects, effect on intestinal flora, and effect on haemostasis of cefotetan. It is also important to investigate the pharmacokinetics and tolerability of cefotetan in different races and ethnicities. 4

Conclusion

Cefotetan is an effective antibiotic for treating various infections. However, it can cause side effects. , 10 , 23 The use of cefotetan should be carefully considered on a case-by-case basis. It is important to discuss the risks and benefits of cefotetan with your doctor before starting treatment.

Literature analysis of 27 papers
Positive Content
22
Neutral Content
2
Negative Content
3
Article Type
5
0
1
1
27
1.

Betalactam therapy and intestinal flora.

Author: NovelliA, MazzeiT, FallaniS, DeiR, CassettaM I, ContiS

Bronchitis treatment

Cefetamet-pivoxil (CET) had a minimal impact on normal human intestinal flora compared to cefixime (CFX) and cefuroxime axetil (CA), which significantly affected Enterobacteriaceae and clostridia. CFX and CA also led to an increase in enterococci and the appearance of Salmonella spp. and Clostridium difficile in some cases.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Maternal anaphylactic shock in pregnancy: A case report.

Author: JeonHye Ji, RyuAeli, MinJiwon, KimNan Seol

Favorable perinatal outcome
Anaphylaxis
Maternal hypotension

A pregnant woman presented with anaphylaxis following cefotetan administration for cesarean section prophylaxis. Prompt management with epinephrine, glucocorticoid, and antihistamine, along with emergency cesarean section, resulted in favorable maternal and fetal outcomes.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Oral and intramuscular treatment options for early postpartum endometritis in low-resource settings: a systematic review.

Author: Meaney-DelmanDana, BartlettLinda A, GravettMichael G, JamiesonDenise J

Effective treatment options
Poor quality evidence
Potential for side effects

This review suggests five antimicrobial regimens that may be effective for the treatment of early postpartum endometritis after vaginal delivery in low-resource settings: oral clindamycin plus intramuscular gentamicin, oral amoxicillin-clavulanate, intramuscular cefotetan, intramuscular meropenem or imipenem-cilastatin, and oral amoxicillin in combination with oral metronidazole.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Pharmacokinetics and tolerability of intravenous cefotetan disodium for injection in healthy Chinese volunteers: A randomized, open-label, single- and multiple-dose study.

Author: ShiShaojun, LiuYani, LiZhongfang, ZhengHeng, LvYongning, ChenHui

Bactericidal effects

Cefotetan disodium is a semisynthetic cephamycin antibiotic that is widely used to treat infections. This abstract describes the pharmacokinetic properties of cefotetan disodium in Chinese subjects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

[Effectiveness of cefotetan in clinical practice].

Author: VinogradovaM A, KozkoT D, PetukhovE M, ShubinaV A, ShneĭterI I, MiroshinaT I, VinogradovN A, Astaf'evaT A, AstakhovaZ N, BokovI B, RogovaiaK I, MaksimovaV I, PetrushinaV S, PredtechenskaiaT I

Cefotetan treatment
Effective treatment
Nausea
Painful injections

Cefotetan, an antibiotic, was found to be effective in treating various infections, including pulmonary affections, skin and subcutaneous infections, and pyoseptic conditions. The drug was generally well tolerated with minimal side effects, mainly limited to mild nausea and injection site discomfort.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

7.

Bactericidal effect of beta-lactams and amikacin alone or in association against Klebsiella pneumoniae producing extended spectrum beta-lactamase.

Author: Roussel-DelvallezM, SirotD, BerrouaneY, GoffartM, GourdeB, WalletF, CourcolR J

Klebsiella pneumoniae infection treatment

Cefotaxime plus co-amoxiclav, a combination of antibiotics, was as effective as imipenem in treating infections caused by extended spectrum beta-lactamase-producing Klebsiella pneumoniae.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Comparison of single-dose cefotetan and multidose cefoxitin as intravenous prophylaxis in elective, open biliary tract surgery: a multicentre, double-blind, randomized study.

Author: LapointeR W, RoyA F, TurgeonP L, LewisR T, DagenaisM H, JolyJ R, ScudamoreC H, RoyP D, ConlyJ M, SyrotuikJ

Reduced infection risk
Rash

Cefotetan was as effective as cefoxitin in preventing infections after biliary tract surgery, with a 1.8% infection rate for cefotetan. Both drugs had a similar rate of side effects, with 12.6% for cefotetan and 10.4% for cefoxitin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

In vitro antibacterial activity of cefoxitin and cefotetan and pharmacokinetics in dogs.

Author: PetersenS W, RosinE

Cefotetan effective
E. coli treatment

Cefotetan was more effective than cefoxitin against Escherichia coli in vitro. In a study of 50 clinical isolates, cefotetan showed a higher susceptibility rate and lower MIC90 than cefoxitin. Cefotetan also maintained effective plasma concentrations for longer periods after intravenous and subcutaneous administration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Cefotetan disodium-induced hemolytic anemia.

Author: WagnerB K, HeatonA H, FlinkJ R

Hemolytic anemia

Cefotetan disodium can cause fulminant hemolytic anemia.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

[Antibiotic prophylaxis in cesarean sections without high risk of infection. Therapeutic trial of cefotetan versus placebo].

Author: RacinetC, MallaretM R, FavierM, BerthetJ, MorelI, FauconnierJ, BrunieJ, DoublierC

Lower cost
Reduced hospital stay
Reduced infection rate

Cefotetan prophylaxis is effective in reducing postoperative infection rates in caesarean sections without a high risk of infection, leading to reduced hospital stays and lower costs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

12.

[Local irritancy study of cefpirome sulfate].

Author: SatohR, YajimaR, MoriokaH, InazuM, GotoK, TanakaT, OmosuM, KobayashiT

Hemolysis

Cefpirome sulfate was found to be well-tolerated in rabbits with minimal local irritancy and no significant adverse effects on male sexual development in juvenile rats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

13.

[Effects of cefpirome sulfate on male sexual development in rats].

Author: AkaikeM, InazuM, OhnoH, TakayamaK, OmosuM, KobayashiT

Cefpirome sulfate did not cause any detrimental effects on male sexual development in juvenile rats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

16.

[Economic benefit of using antibiotics prophylactically in cesarean sections with little risk of infection].

Author: MallaretM R, BlatierJ F, RacinetC, FauconnierJ, FavierM, MicoudM

Cost-effective
Reduced infection
Shorter hospital stay
None reported

Prophylactic antibiotics were effective in reducing post-Caesarean morbidity due to endometritis, superficial and deep abscesses, and septicaemia. The length of hospital stay was significantly reduced in the group that received prophylactic antibiotics.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

17.

Absolute bioavailability and noncompartmental analysis of intravenous and intramuscular Cefotan (cefotetan) in normal volunteers.

Author: ZimmermanJ, CohenA, ThyrumP

Rapid absorption

Cefotetan, an antibiotic, was rapidly and almost completely absorbed after intramuscular injection. It was excreted primarily in the urine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Efficacy and safety of cefotetan in the treatment of complicated urinary tract infections: clinical experience in a selective and single study.

Author: GesualdoL, QuartoM, ViggianiN, GerminarioC, BarbutiS, SchenaF P

Cured UTI
Effective against pluri-resistant organisms
Reinfection
Relapse
Side effects
Superinfection

Cefotetan is effective in treating complicated urinary tract infections caused by sensitive organisms. It is well-tolerated, but side effects can occur.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

[The influence of a monobactam antibiotic, aztreonam, and other antibiotics on blood coagulation in vitamin K-deficient rats].

Author: AkiyamaY, HaraK, KatoY, TakizawaK, SatoM, TajimaT

Less likely to induce hypoprothrombinemia

Aztreonam, a monobactam antibiotic, was less likely to induce hypoprothrombinemia than other antibiotics, including latamoxef, cefoperazon, cefotetan, and ampicillin.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

20.

Serum bactericidal activity against aerobes and anaerobes of volunteers receiving cefoxitin or cefotetan.

Author: CrucianiM, NavarraA, BonoL, ConciaE

High serum bactericidal activity
None

Cefotetan showed higher serum bactericidal activity against both aerobic and anaerobic bacteria compared to cefoxitin.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

[Five-week subacute intravenous toxicity study of cefodizime sodium in dogs].

Author: NakanoS, YadaH, IrimuraK, KurokawaK, HirotaT, MoritaK

Antibacterial
Fibrosis
Granulation
Salivation
Vomiting

Cefodizime sodium (THR-221) was less toxic than cefotetan in dogs. While some side effects were observed at higher doses, the drug was well tolerated overall.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

22.

[Local irritation studies of cefodizime sodium].

Author: YamakitaO, KoidaM, ShinomiyaM, ImamuraK, NakagawaM, KashiharaA, IrimuraK, TanakaG, YoshidaR

Antibacterial
Muscle irritation
Vessel irritation

Cefodizime sodium (THR-221), a new cephem antibiotic, was tested for local irritation in rabbits. It caused mild irritation in muscle and blood vessels, but was less irritating than other cephem antibiotics. Repeated injections at the same site should be avoided in clinical use.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

24.

The effects of cefotetan disodium on haemostasis.

Author: CohenH, MackieI J, WalsheK, ShearerM, BaxR, PozniakA, MoulsdaleM, MachinS J

Increased platelet aggregation
No bleeding diathesis
Prolonged bleeding time
Vitamin K1 deficiency risk

Cefotetan disodium, an intravenous antibiotic, was found to be safe for use, without risk of bleeding diathesis, but with a potential for prolonging prothrombin time in cases of vitamin K1 deficiency.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

25.

Evaluation of cefotetan in uncomplicated gonorrhea.

Author: KortingH C, AbeckD, NeubertU

Gonorrhea Treatment

Cefotetan, a cephamycin resistant to bacterial beta-lactamase, was tested for its in vitro activity against Neisseria gonorrhoeae and clinical efficacy in uncomplicated gonorrhea. 90% of the strains were inhibited by 0.5 micrograms/ml of cefotetan. A single 1g intramuscular injection cured 92.3% of 52 patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

26.

Single-dose cefotetan for urinary tract infection.

Author: SandersonP J

UTI treatment
Side effects

Cefotetan (2 g IM) was effective in treating lower urinary tract infection in 7 patients. Minor side effects were reported in two patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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