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Treatment of HBeAg-negative chronic hepatitis B patients with nucleos(t)ide analogues.

Author: PapatheodoridisGeorge V

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Nucleos(t)ide analogues (NUCs) are the preferred treatment for chronic hepatitis B (CHB) due to their ease of use, good tolerability, and high potency against the virus. Entecavir and tenofovir are the most potent NUCs and have the lowest risk of resistance development. While NUCs require long-term therapy, they may be safely discontinued in HBeAg-positive patients with stable HBeAg seroconversion.
Paper Details　
Original Abstract of the Article :
Current agents used in the treatment of chronic hepatitis B (CHB) can be classified into interferons-α (IFN-α: standard or pegylated) and nucleos(t)ide analogues (NUCs). NUCs are now used in most CHB patients for several reasons. They can be given to all CHB patients, even those with contraindicatio...See full text at original site
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引用元：
https://doi.org/10.1111/j.1478-3231.2010.02392.x

データ提供：米国国立医学図書館（NLM）

Treatment of Chronic Hepatitis B: Finding a Path Through the Desert of Infection

Chronic hepatitis B, a persistent and potentially serious liver infection, can feel like a vast and unforgiving desert, with patients facing ongoing challenges and risks. This study explores the use of nucleos(t)ide analogues (NUCs), a class of antiviral drugs, in the treatment of HBeAg-negative chronic hepatitis B patients.

The researchers embarked on a journey across the desert of hepatitis B treatment, examining the effectiveness of NUCs in controlling viral replication and preventing liver damage. They found that NUCs, like a reliable oasis, offer a powerful and well-tolerated treatment option, providing long-term viral suppression and improving long-term outcomes. While NUCs require long-term, even indefinite treatment, they have minimal side effects, making them a more manageable solution compared to other therapies.

NUCs: A Sustainable Oasis in the Desert of Hepatitis B

The study underscores the effectiveness of NUCs in managing HBeAg-negative chronic hepatitis B. These drugs, like a sustainable oasis, provide long-term viral suppression and improved outcomes for patients, offering a more manageable path through the desert of infection.

Navigating the Long-Term Treatment Landscape

This research highlights the importance of long-term management for chronic hepatitis B. NUCs, while effective, require ongoing treatment, highlighting the need for careful patient monitoring and communication. Like desert nomads who must adapt to the changing environment, patients and healthcare providers must work together to navigate this long-term treatment landscape.

Dr. Camel's Conclusion

The desert of chronic hepatitis B is vast and complex. This research shines a light on the effectiveness of NUCs, providing a beacon of hope for patients seeking long-term management of this challenging condition. While the journey may be long, NUCs offer a sustainable oasis, ensuring patients can navigate the desert of infection with greater control and well-being.

Date :
  1. Date Completed 2011-05-17
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

21205145

DOI: Digital Object Identifier

10.1111/j.1478-3231.2010.02392.x

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