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Evaluation of menstrual cycle effects on morphine and pentazocine analgesia.

Author: FillingimR B, GloverT, Ribeiro-DasilvaM C, RileyJ L, ShinalR M, StaudR, WilliamsR S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

The study found that morphine analgesia and side effects were greater during the follicular phase of the menstrual cycle. This suggests that sex hormones may influence opioid responses, but these effects vary across medications and pain modalities and are likely to be modest in magnitude.
Paper Details　
Original Abstract of the Article :
Studies have demonstrated menstrual cycle influences on basal pain perception, but direct evidence of menstrual cycle influences on analgesic responses has not been reported in humans. Our aim was to determine whether the magnitude of morphine and pentazocine analgesia varied across the menstrual cy...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://pubmed.ncbi.nlm.nih.gov/21239109

データ提供：米国国立医学図書館（NLM）

Menstrual Cycle's Hidden Influence on Pain Perception

The intricacies of the female body are a constant source of fascination and intrigue. This research, like a curious explorer venturing into a hidden cave, delves into the world of menstrual cycle influences on pain perception and analgesic responses. This study, conducted with the precision of a seasoned camel caravan, investigates the potential impact of hormonal fluctuations on the body's response to pain relief.

Hormonal Tides: Shaping Pain Perception

The study found that the menstrual cycle can influence both pain perception and the effectiveness of analgesics, particularly morphine. It's like discovering that the ebb and flow of the desert tides, while seemingly insignificant, can impact the flow of water through the ecosystem. Women experiencing their menstrual cycle may experience greater sensitivity to pain during the follicular phase and a stronger response to morphine during this time.

Navigating the Desert of Pain

This research highlights the need for personalized approaches to pain management, taking into account the individual's menstrual cycle and potential hormonal influences. It's like recognizing that the desert is a diverse landscape, with different terrains requiring unique strategies for successful navigation.

Dr.Camel's Conclusion

The study's findings, like a hidden oasis discovered after a long trek, shed light on the intricate relationship between the menstrual cycle and pain perception. It underscores the importance of understanding these individual differences to optimize pain management strategies.

Date :
  1. Date Completed 2011-06-16
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21239109

DOI: Digital Object Identifier

NIHMS258931

Related Literature

Article Analysis
・Side Effects of pentazocine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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