Side Effects of pentazocine: A Synthesis of Findings from 24 Studies

  1. Home
  2. Side Effects of pentazocine
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of pentazocine: A Synthesis of Findings from 24 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of pentazocine: A Synthesis of Findings from 24 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Pentazocine is a widely used medication to alleviate pain. The studies show that pentazocine administration may lead to various side effects, which vary depending on administration time, method, and individual differences. 2 investigated the pharmacokinetics and clinical side effects of pentazocine when administered during the day and night. They found no significant differences in clinical effects between day and night. However, two volunteers from Europe demonstrated significant differences in the volume of distribution. This suggests that the biological clock shift or jet lag may affect drug disposition. 19 investigated the effects of the menstrual cycle on the analgesic effects of morphine and pentazocine. They found that women with normal menstrual cycles had stronger morphine analgesic effects during the follicular phase compared to the luteal phase. No significant difference in pentazocine effect was observed due to menstrual cycle. 12 reported a case of skin abscesses and myofibrosis in both lower limbs following repeated intramuscular injection of pentazocine, along with tuberculosis infection. This highlights the potential for repeated intramuscular pentazocine injection to cause skin inflammation and tissue damage. 18 observed the effects and side effects of pentazocine in patients with lumbar hernia undergoing intravenous analgesia after surgery. The results showed that pentazocine was effective for postoperative analgesia, but dose-dependent side effects were observed. These studies suggest a range of side effects associated with pentazocine administration and underscore the need for careful administration and close monitoring for side effects.

Reasons for Side Effects

The side effects of pentazocine are linked to its action on opioid receptors. Pentazocine acts as a partial agonist at the μ-opioid receptor and as an agonist at the κ-opioid receptor. The μ-opioid receptor is associated with analgesic effects, dependence, respiratory depression, constipation, and other side effects. The κ-opioid receptor is associated with analgesic effects, respiratory depression, nausea, vomiting, psychomotor impairment, and hallucinations. Side effects of pentazocine vary depending on its action on these receptors and individual differences.

Common Side Effects

Nausea and Vomiting

Nausea and vomiting are common side effects of pentazocine. 19 found that women with normal menstrual cycles experienced more nausea as a side effect of morphine during the follicular phase than during the luteal phase. 20 suggests that pentazocine may be effective in treating itching associated with morphine.

Dizziness

Pentazocine can cause dizziness. 1 shows that pentazocine can cause cognitive and affective side effects, as well as somatic side effects.

Drowsiness

Pentazocine can cause drowsiness. 1 shows that pentazocine can cause cognitive and affective side effects, as well as somatic side effects.

Rash

Pentazocine can cause allergic reactions such as rash. However, rash caused by pentazocine is relatively uncommon.

Respiratory Depression

Pentazocine can cause respiratory depression. 1 shows that pentazocine can cause cognitive and affective side effects, as well as somatic side effects.

Dependence

Pentazocine can cause dependence. 1 shows that pentazocine can cause cognitive and affective side effects, as well as somatic side effects. Pentazocine, like other opioids, can cause dependence. Frequent or long-term use of pentazocine increases the risk of dependence. It is important to use pentazocine as directed by your doctor to minimize the risk of dependence.

Mental Disorders

Pentazocine can cause mental disorders such as hallucinations, confusion, anxiety, depression, and psychomotor agitation. 1 shows that pentazocine can cause cognitive and affective side effects, as well as somatic side effects. These side effects are thought to be caused by pentazocine's stimulation of the κ-opioid receptor. It is important to use pentazocine as directed by your doctor to minimize the risk of mental disorders.

Countermeasures for Side Effects

Nausea and Vomiting

Nausea and vomiting caused by pentazocine can be alleviated by taking the medicine before meals or drinking plenty of fluids after taking the medicine. It may also be effective to get an antiemetic prescribed by your doctor. If you experience severe nausea and vomiting, stop taking the medicine and consult your doctor.

Dizziness

Dizziness caused by pentazocine can be alleviated by avoiding standing up or moving suddenly for a while after taking the medicine. If you experience severe dizziness, stop taking the medicine and consult your doctor.

Drowsiness

Drowsiness caused by pentazocine can be alleviated by avoiding tasks that require attention, such as driving or operating dangerous machinery. If you feel drowsy, get plenty of rest. If you experience severe drowsiness, stop taking the medicine and consult your doctor.

Rash

If you develop a rash caused by pentazocine, stop taking the medicine and consult your doctor. The doctor will determine the cause of the rash and recommend an appropriate treatment.

Respiratory Depression

Respiratory depression caused by pentazocine manifests as shallow breathing, low respiratory rate, or cessation of breathing. If you experience these symptoms, stop taking the medicine immediately and consult your doctor. Severe respiratory depression can be life-threatening.

Dependence

Pentazocine can cause dependence. To prevent dependence, it is important to use pentazocine as directed by your doctor. Frequent or long-term use of pentazocine increases the risk of dependence. It is important to use pentazocine as directed by your doctor to minimize the risk of dependence.

Mental Disorders

Pentazocine can cause mental disorders such as hallucinations, confusion, anxiety, depression, and psychomotor agitation. If you experience these side effects, stop taking the medicine and consult your doctor. Severe mental disorders can be life-threatening.

Comparison between Studies

Common Points of Studies

These studies suggest that pentazocine can cause a variety of side effects. However, it has been found that the incidence and severity of side effects vary greatly from person to person. Pentazocine is also thought to have a lower risk of dependence compared to other opioids such as morphine.

Differences between Studies

These studies reveal various aspects of pentazocine's side effects. For example, 2 investigated the difference in side effects depending on the time of administration of pentazocine, and 19 investigated the difference in side effects depending on the menstrual cycle of women. These studies suggest that pentazocine's side effects are influenced by various factors.

Precautions for Application to Daily Life

While pentazocine has pain-relieving effects, it can also cause various side effects. When taking pentazocine, it is important to consult with your doctor and take the appropriate dosage and method of administration as directed. If you experience any side effects while taking pentazocine, stop taking the medicine immediately and consult your doctor. Pentazocine may interact with other medications, so consult your doctor if you are taking other medications. This is especially important if you are taking other opioids, benzodiazepines, alcohol, or tranquilizers. Also, if you are pregnant or breastfeeding, consult your doctor before taking pentazocine.

Limitations of Current Research

There is still not enough research on pentazocine. In particular, there is a lack of research on the long-term effects of pentazocine and the side effects in specific populations. Therefore, further research is needed to fully understand the safety of pentazocine.

Future Directions for Research

Further research on pentazocine's side effects is needed. In particular, research on long-term effects, side effects in specific populations, and interactions with other medications is needed. These studies can lead to a better understanding of pentazocine safety and promote its safer use.

Conclusion

Pentazocine has pain-relieving effects, but it can also cause various side effects. When taking pentazocine, it is important to consult with your doctor and take the appropriate dosage and method of administration as directed. If you experience any side effects while taking pentazocine, stop taking the medicine immediately and consult your doctor. Further research is needed to fully understand the safety of pentazocine.

Literature analysis of 24 papers
Positive Content
18
Neutral Content
2
Negative Content
4
Article Type
7
0
1
3
23
1.

Cognitive-affective and somatic side effects of morphine and pentazocine: side-effect profiles in healthy adults.

Author: RileyJoseph L, HastieBarbara A, GloverToni L, FillingimRoger B, StaudRoland, CampbellClaudia M

Cognitive side effects
Somatic side effects

This study examined the subjective effects of morphine and pentazocine on somatic and cognitive/affective side effects using questionnaires.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

2.

Disposition and clinical side effects of pentazocine when administered during day and night.

Author: RitschelW A, BykadiG, HoffmannK A, NormanE J, LückerP W, RindtW

Pentazocine's pharmacokinetic profile does not appear to be significantly influenced by circadian rhythm. However, the clinical effects of the drug are more pronounced after the first dose than after the second dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

A Comparison of Two Regimens for Post-Caesarean Section Analgesia in a Tertiary Health Centre in Northern Nigeria.

Author: EkweaniJ, Ogboli-NwasorE, MaduguH N, AvidimeS

Post-caesarean section pain
Side effects

This study examines the efficacy and safety of alternating doses of intramuscular acetaminophen and pentazocine for post-caesarean section pain management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

The efficacy of pentazocine + diclofenac versus paracetamol + diclofenac for post- caesarean section analgesia.

Author: GarbaJamila Abubakar, PantiAbubakar Abubakar, NnadiDaniel C, AngoIbrahim G, TunauKarima A, BelloSaratu, ZubairuSaad, NasirAsmau'u Muhammad, IbrahimRukayya

Pain relief
Side effects

This single-blind, randomized trial compared the efficacy of pentazocine + diclofenac and paracetamol + diclofenac for post-operative analgesia after caesarean section. Both combinations provided adequate analgesia, but pentazocine + diclofenac showed slightly better pain relief but was associated with more side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials.

Author: Ching WongStanley Sau, CheungChi Wai

Analgesic benefit
Opioid safety

Meperidine is a synthetic opioid with a rapid onset and short duration of action. Despite concerns about its safety and mounting evidence challenging its analgesic benefits, meperidine remains frequently used.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

PENTAZOCINE VERSUS PENTAZOCINE WITH RECTAL DICLOFENAC FOR POSTOPERATIVE PAIN RELIEF AFTER CESAREAN SECTION- A DOUBLE BLIND RANDOMIZED PLACEBO CONTROLLED TRIAL IN A LOW RESOURCE AREA.

Author: OlatejuSimeon O, AdenekanAnthony T, OlufolabiAdeyemi J, OwojuyigbeAfolabi M, AdetoyeAdedapo O, AjenifujaKayode O, OlowookereSamuel A, FaponleAramide F

Increased satisfaction
Pain relief

Combining rectal diclofenac with intramuscular pentazocine is more effective in reducing pain after cesarean section than intramuscular pentazocine alone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Multiple Skin Abscesses and Myofibrosis of Bilateral Lower Limbs Following Repeated Intramuscular Injection of Pentazocine with Concomitant Tuberculous Infection.

Author: AgasheVikas M, PatilHitendra, GundavdaManit K

Abnormal skin pigmentation
Fibrous myopathy
Skin abscesses
Skin fibrosis
Ulceration

Pentazocine abuse can lead to severe complications, including abscesses, polymicrobial infection, and fibrous myopathy. Awareness of these complications is important to prevent unwanted side effects.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

13.

[Study on the preemptive analgesia effects of both the parecoxib sodium and the pentazocine in patients undergoing nasal endoscopic surgery].

Author: KongYonggang, YangXilin

Reduced pain
Reduced rescue medication

This study evaluated the preemptive analgesia effects of parecoxib sodium and pentazocine in patients undergoing nasal endoscopic surgery. The study found that both parecoxib and pentazocine provided preemptive analgesia without serious adverse side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

14.

Paravertebral block for video-assisted thoracoscopic surgery: analgesic effectiveness and role in fast-track surgery.

Author: KomatsuTeruya, KinoAtsunari, InoueMari, SowaTerumasa, TakahashiKoji, FujinagaTakuji

Postoperative analgesia

This article discusses the use of paravertebral block (PVB) versus thoracic epidural blockade (TEB) for postoperative analgesia in video-assisted thoracoscopic surgery (VATS). While PVB has been reported to be as effective as TEB, it is not often used due to the challenges of thoracoscopic catheter insertion. The article suggests that further research is needed to improve PVB techniques and promote its wider use in VATS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

16.

A COMPARATIVE STUDY OF INTRAMUSCULAR ACETAMINOPHEN VERSUS INTRAMUSCULAR PENTAZOCINE AS LABOUR ANALGESIA IN ZARIA, NORTHWESTERN NIGERIA.

Author: EkweaniJ C, AdesiyunA G, Ogboli-NwasorE, AvidimeS

Comparable pain relief
Fewer side effects

Intramuscular acetaminophen provided comparable labor analgesia with fewer side effects compared to pentazocine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

[Clinical observation of pentazocine for postoperative intravenous analgesia in patients with lumbar herniation].

Author: XuHui-Qing, XingJian-Min, JiaRuo

Postoperative analgesia
Reduced adverse effects
Dizziness
Nausea
Pruritus
Respiratory depression
Vomiting

Pentazocine produced reliable postoperative analgesia for patients with lumbar herniation with fewer adverse effects than sufentanil. 3 mg/kg of Pentazocine was found to be the optimal dose.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Chinese

19.

Evaluation of menstrual cycle effects on morphine and pentazocine analgesia.

Author: Ribeiro-DasilvaM C, ShinalR M, GloverT, WilliamsR S, StaudR, RileyJ L, FillingimR B

Analgesic responses
Menstrual cycle influence
Pain perception
Modest effects
Side effects

The study found that morphine analgesia and side effects were greater during the follicular phase of the menstrual cycle. This suggests that sex hormones may influence opioid responses, but these effects vary across medications and pain modalities and are likely to be modest in magnitude.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

20.

A randomized controlled trial of pentazocine versus ondansetron for the treatment of intrathecal morphine-induced pruritus in patients undergoing cesarean delivery.

Author: TamdeeDecha, CharuluxanananSomrat, PunjasawadwongYodying, TawichasriChamaiporn, PatumanondJayanton, SriprajittichaiPin

Intrathecal Morphine-Induced Pruritus Treatment

Pentazocine, a kappa-opioid receptor agonist, was found to be effective for treating intrathecal morphine-induced pruritus in patients undergoing cesarean delivery, similar to the efficacy of ondansetron.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

The chemical and pharmacological importance of morphine analogues.

Author: FürstS, HosztafiS

Pain relief
Reduced addiction risk
Dependence
Side effects

This review summarizes the efforts to discover therapeutically useful morphine-like drugs. The search has involved developing analgesics with high efficacy and reduced side effects, understanding structure-activity relationships, and investigating the mechanism of pain perception.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

WITHDRAWN: Types of intra-muscular opioids for maternal pain relief in labour.

Author: ElbourneD, WisemanR A

Pain relief
Adverse effects
Insufficient evidence

There is not enough evidence to evaluate the comparative efficacy and safety of the various opioids used for analgesia in labour.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

[Optimal dose of fentanyl for postoperative epidural analgesia after cesarean section].

Author: ShirasakaTetsuro, YonahaTetsu, OokuboShigeaki, NishimuraEmi, KashiwadaMasatoshi, TakasakiMayumi

Pain relief
Nausea
Pruritus
Vomiting

Continuous epidural administration of fentanyl 21 microg x hr(-1) with ropivacaine provides the optimum balance between pain relief and side effects compared with fentanyl 11 microg x hr(-1) with ropivacaine after cesarean section (CS).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Japanese

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.