Effect of memantine on resting state default mode network activity in Alzheimer's disease.

Author: AlessandriniFranco, BeltramelloAlberto, CaltagironeCarlo, CanuElisa, CostardiDaniela, CotelliMaria, FrisoniGiovanni B, LorenziMarco, MercuriNicola B, PizziniFrancesca B, RosiniSandra, ZoccatelliGiada

Paper Details 
Original Abstract of the Article :
Memantine is an approved symptomatic treatment for moderate to severe Alzheimer's disease that reduces the excitotoxic effects of hyperactive glutamatergic transmission. However, the exact mechanism of the effect of memantine in Alzheimer's disease patients is poorly understood. Importantly, the def...See full text at original site
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引用元:
https://doi.org/10.2165/11586440-000000000-00000

データ提供:米国国立医学図書館(NLM)

Memantine and the Brain's Default Mode Network: A Journey into Alzheimer's Disease

Alzheimer's disease, a devastating neurological condition, affects millions worldwide. This study delves into the role of memantine, a medication used to treat Alzheimer's, in the brain's default mode network (DMN). The DMN is like a bustling desert city, constantly active, playing a crucial role in attention and cognitive function. The study explores how memantine might influence this vital network in Alzheimer's patients.

Memantine: A Potential Oasis in the Desert of Alzheimer's

While memantine is known to reduce the harmful effects of excessive glutamate in the brain, its exact mechanism of action in Alzheimer's disease is still being explored. The researchers are seeking clues like explorers uncovering ancient artifacts in the sands of time. Understanding how memantine interacts with the DMN could pave the way for more effective treatments for Alzheimer's.

A Beacon of Hope in the Alzheimer's Desert

This study offers a glimmer of hope in the vast desert of Alzheimer's research. The DMN is a vital network, and understanding how memantine interacts with it could lead to innovative therapeutic strategies. It's a reminder that even in the most challenging landscapes, new discoveries can emerge, offering pathways to better health and well-being.

Dr. Camel's Conclusion

Alzheimer's disease is a formidable opponent, but researchers are relentlessly searching for solutions. This study, like a lone camel venturing into a seemingly barren desert, explores the potential of memantine to positively influence the brain's default mode network. The journey is ongoing, but the pursuit of understanding and effective treatments for Alzheimer's is vital, bringing hope to those affected and their loved ones.

Date :
  1. Date Completed 2011-08-15
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21250762

DOI: Digital Object Identifier

10.2165/11586440-000000000-00000

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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