Immunogenicity and safety of human papillomavirus-16/18 AS04-adjuvanted vaccine administered according to an alternative dosing schedule compared with the standard dosing schedule in healthy women aged 15 to 25 years: results from a randomized study.

Author: BirlutiuVictoria, DescampsDominique, DobbelaereKurt, EspositoSusanna, JarcuskaPavol, ManSorin Claudiu, MericDorothée, PerinoAntonio, ThomasFlorence, VladareanuRadu

Paper Details 
Original Abstract of the Article :
The human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine is immunogenic, has a clinically acceptable safety profile, and prevents incident and persistent HPV-16/18 infection and cervical precancerous lesions. This study (NCT00552279) evaluated the vaccine when administered according to an altern...See full text at original site
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引用元:
https://doi.org/10.1097/INF.0b013e318206c26e

データ提供:米国国立医学図書館(NLM)

HPV Vaccine: An Alternative Dosing Schedule

The human papillomavirus (HPV) vaccine is a powerful tool in the fight against cervical cancer. This study, like a skilled engineer optimizing a machine, investigates the immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine when administered according to an alternative dosing schedule (0-1-12 months) compared to the standard schedule (0-1-6 months). The research aims to explore the effectiveness of this alternative dosing regimen while ensuring its safety.

Flexibility in Vaccination

The study found that the alternative dosing schedule (0-1-12 months) was as immunogenic as the standard schedule (0-1-6 months), meaning it produced a comparable immune response. The research also confirmed the safety of the alternative schedule. These findings, like a well-traveled desert route, offer flexibility in vaccine administration, potentially enhancing accessibility and convenience for individuals.

Improving Vaccine Accessibility

The study's results have significant implications for public health initiatives. The findings suggest that the alternative dosing schedule could potentially improve vaccine accessibility and convenience, especially for individuals with busy schedules or limited access to healthcare. This flexibility could contribute to higher vaccination rates and ultimately reduce the incidence of HPV-related diseases.

Dr. Camel's Conclusion

Just as a wise camel adapts to the terrain, scientists are constantly seeking ways to improve the effectiveness and accessibility of vaccines. This study, like a well-worn path across the desert, explores an alternative dosing schedule for the HPV vaccine. The findings suggest that this flexible approach could potentially increase vaccination rates and ultimately contribute to the prevention of HPV-related diseases.

Date :
  1. Date Completed 2011-05-24
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

21273939

DOI: Digital Object Identifier

10.1097/INF.0b013e318206c26e

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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