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Dissociation of the attentional and motivational effects of pimozide on the threshold for rewarding brain stimulation.

Author: BirdM, KornetskyC

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Pimozide selectively inhibits the rewarding effects of brain stimulation, suggesting a role for the D2 dopamine receptor in activating central reward pathways. This may explain the dual anhedonic/antipsychotic effects of neuroleptic medication.
Paper Details　
Original Abstract of the Article :
The decreased sensitivity of animals to rewarding brain stimulation caused by pimozide has been interpreted as a selective pharmacologic blockade of central reward pathways rather than a nonspecific disruption of performance. In an attempt to confirm this hypothesis, the effects of pimozide on both ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2137697

データ提供：米国国立医学図書館（NLM）

Decoding the Role of Dopamine in Reward Processing

Understanding the mechanisms underlying [reward processing] is a crucial step in unraveling the complexities of [motivation] and [behavior]. This research investigates the effects of pimozide, a dopamine receptor blocker, on the reward and detection thresholds for electrical brain stimulation in the medial forebrain bundle (MFB).

Pimozide's Selective Effect on Reward Pathways

The study reveals that pimozide selectively inhibits the rewarding effects of brain stimulation without affecting the detection threshold, suggesting that dopamine receptors play a significant role in activating central reward pathways.

The Implications of Dopamine for Motivation and Behavior

This research sheds light on the crucial role of dopamine in reward processing, providing valuable insights into the neural mechanisms underlying motivation and behavior. It highlights the importance of dopamine receptors in regulating our drive to seek pleasure and rewards.

Dr.Camel's Conclusion

Much like a caravan crossing the vast desert, this study navigates the complex landscape of reward processing, revealing the vital role of dopamine in motivating our actions. The research highlights the intricate interplay between dopamine and reward pathways, offering a deeper understanding of the mechanisms that drive our behavior.

Date :
  1. Date Completed 1990-04-05
  2. Date Revised 2015-03-11
Further Info :

Pubmed ID

2137697

DOI: Digital Object Identifier

2137697

Related Literature

Article Analysis
・Effects of pimozide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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