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Evaluation of brain anticholinergic activities of urinary spasmolytic drugs using a high-throughput radio receptor bioassay.

Author: JakobsenStine Mjåvatn, KerstenHege, MoldenEspen

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Tolterodine and fesoterodine have the highest pharmacodynamic potential to induce central anticholinergic side effects. Darifenacin exhibited the lowest anticholinergic activity, suggesting a more favorable pharmacological profile with respect to cognitive impairment in older adults.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To compare the brain anticholinergic activities of five urinary spasmolytic drugs (USDs). DESIGN: In vitro study. SETTING: Laboratory. PARTICIPANTS: None. MEASUREMENTS: A validated 96-well anticholinergic radio receptor bioassay using small incubation volumes (240 μL per well) was ap...See full text at original site
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引用元：
https://doi.org/10.1111/j.1532-5415.2010.03307.x

データ提供：米国国立医学図書館（NLM）

Brain Anticholinergic Activities of Urinary Spasmolytic Drugs: A Comparative Study

Urinary spasmolytic drugs are commonly used to treat urinary incontinence. This research investigates the brain anticholinergic activities of five different urinary spasmolytic drugs: tolterodine, oxybutynin, solifenacin, darifenacin, and 5-hydroxy-methyl-tolterodine (5-HMT). The study utilized a high-throughput radio receptor bioassay to assess the anticholinergic potency of these drugs in the brain.

Anticholinergic Activity: A Potential for Cognitive Side Effects

The study found that tolterodine and 5-HMT exhibited the highest brain anticholinergic activity, suggesting a potential for cognitive side effects, particularly in older adults. It's like encountering a mirage in the desert - a tempting but illusory vision. The study highlights the importance of considering the potential for central anticholinergic side effects when prescribing these drugs.

Considerations for Patient Safety

The research underscores the need for careful consideration of individual patient factors, particularly age and cognitive function, when prescribing urinary spasmolytic drugs. It's a reminder that just as the desert can be unforgiving, medications can have unintended consequences. Healthcare professionals should weigh the potential benefits and risks of these drugs, particularly for individuals at risk of cognitive impairment.

Dr.Camel's Conclusion

This research sheds light on the complex interplay between medications and the brain. It's a reminder that just as the desert holds secrets waiting to be unraveled, the world of medicine continues to explore the intricate relationships between drugs and the human body. The study emphasizes the importance of understanding the potential for central anticholinergic side effects, particularly in vulnerable populations, and highlights the need for careful prescribing practices to ensure patient safety.

Date :
  1. Date Completed 2011-06-02
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

21391941

DOI: Digital Object Identifier

10.1111/j.1532-5415.2010.03307.x

SNS
PICO Info
in preparation
Languages

English

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