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Pharmacokinetic evaluation of palifermin for mucosal protection from chemotherapy and radiation.

Author: HaasRainer, KobbeGuido, WeigeltChristian

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Palifermin has been shown to be an effective treatment for preventing severe oral mucositis in patients with hematological cancers receiving high-dose chemotherapy and total body irradiation and in patients with head and neck cancer receiving combined irradiation and chemotherapy. While the dose and schedule of palifermin needed to achieve protection from mucositis in less mucotoxic regimens are less well defined, the benefit of palifermin must be weighed against its unwanted effects.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Oral mucositis, one of the major side effects of chemotherapy and irradiation, is still a burden of modern oncology. The keratinocyte growth factor (KGF) palifermin has been approved as a new, targeted therapy for the prevention of severe oral mucositis. AREAS COVERED: The authors rev...See full text at original site
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引用元：
https://doi.org/10.1517/17425255.2011.566556

データ提供：米国国立医学図書館（NLM）

Palifermin for Mucosal Protection: A New Oasis in the Desert of Chemotherapy

Chemotherapy is a powerful weapon in the fight against cancer, but it can have significant side effects, including oral mucositis. This study explores the potential of palifermin, a keratinocyte growth factor, to prevent severe oral mucositis, providing a potential oasis of relief for patients undergoing chemotherapy. The researchers, like explorers searching for new solutions, reviewed existing research on palifermin's pharmacokinetics and clinical use. They analyzed data from in vitro studies, clinical trials, and case reports, seeking to understand the optimal dosage, administration schedule, and efficacy of palifermin.

Palifermin: A Promising Shield in the Desert of Side Effects

The study's findings point towards a potentially valuable new tool in the fight against chemotherapy-induced mucositis. Palifermin has shown promise in preventing severe mucositis in patients with hematological cancers receiving high-dose chemotherapy and total body irradiation, as well as in patients with head and neck cancer undergoing combined irradiation and chemotherapy. This suggests that palifermin could offer a protective shield against the harsh side effects of cancer treatment.

Navigating the Desert of Chemotherapy: Finding Relief and Protection

This study is a valuable resource for understanding the potential of palifermin in preventing chemotherapy-induced mucositis. The research provides evidence that palifermin can offer significant protection, potentially improving the quality of life for patients undergoing cancer treatment. It's like finding a haven of protection in the midst of a harsh desert.

Dr.Camel's Conclusion

Palifermin shows promise in protecting patients from the harsh side effects of chemotherapy. This research highlights the importance of developing new approaches to minimize the burden of treatment, allowing patients to navigate the desert of cancer treatment with greater comfort and hope.

Date :
  1. Date Completed 2011-07-07
  2. Date Revised 2013-11-06
Further Info :

Pubmed ID

21417820

DOI: Digital Object Identifier

10.1517/17425255.2011.566556

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・Side Effects of palifermin
SNS
PICO Info
in preparation
Languages

English

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