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Maintenance therapy with continuous or switch strategy in advanced non-small cell lung cancer: a systematic review and meta-analysis.

Author: BaiChong, HeJia, HeQian, LiuKe, QinYingyi, WeiLixin, WuCheng, WuMeijing, XuJinfang, ZangJiajie, ZhangShanshan, ZhangXinji

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Maintenance therapy for non-small cell lung cancer (NSCLC) significantly increases overall survival (OS) and progression-free survival (PFS) compared with placebo or observation. However, the benefits must be balanced against toxicity.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Maintenance therapy for patients with non-small cell lung cancer (NSCLC) has gained extensive interest. Varying results for this treatment underpin the need for a synthesis of evidence. METHODS: Trials investigating maintenance therapy with either a continuous or a switch strategy for p...See full text at original site
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引用元：
https://doi.org/10.1378/chest.10-2745

データ提供：米国国立医学図書館（NLM）

Maintenance Therapy for Lung Cancer: Finding the Right Path

The treatment of advanced non-small cell lung cancer (NSCLC) is like navigating a complex desert maze, with many paths to consider. This research explores the role of maintenance therapy, a strategy aimed at extending the benefits of initial treatment and improving overall survival. The study compares two approaches: continuous maintenance therapy and switch maintenance therapy, evaluating their effectiveness and safety.

The researchers, like skilled desert guides, meticulously analyzed data from multiple clinical trials. Their findings reveal that both continuous and switch maintenance therapy significantly improve progression-free survival compared to placebo or observation. Switch maintenance therapy also showed a statistically significant improvement in overall survival.

The study highlights the importance of maintenance therapy in managing advanced NSCLC, offering valuable insights into the optimal strategies for extending survival and improving quality of life. It underscores the need for careful consideration of the individual patient's needs and the potential risks and benefits of different treatment approaches.

Extending Survival and Improving Quality of Life

This research underscores the importance of maintenance therapy in managing advanced NSCLC, offering potential to extend survival and improve quality of life. It's a reminder that finding the right path in cancer treatment is crucial for achieving the best possible outcome.

Dr. Camel's Conclusion

This research offers valuable insights into the complex world of lung cancer treatment. It's a reminder that the quest for effective treatments is an ongoing journey, much like a camel traversing a vast and unpredictable desert. This study highlights the importance of carefully considering all available treatment options and collaborating with healthcare providers to find the best path for each individual patient.

Date :
  1. Date Completed 2011-09-01
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

21436247

DOI: Digital Object Identifier

10.1378/chest.10-2745

Related Literature

Article Analysis
・Effective treatment of lung cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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