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Influence of danazol and goserelin on insulin and glucagon in non-obese women with endometriosis.

Author: ElsteinM, GollandI M, LaingI, ShaletS M, Vaughan-WilliamsC A

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

This study examined the effects of two treatments for endometriosis on hormone levels in 12 women: danazol and goserelin. Danazol significantly increased insulin and glucagon levels, but not testosterone levels. Goserelin did not affect any of these hormones. This suggests that the increased insulin and glucagon levels seen with danazol are not due to the increase in testosterone.
Paper Details　
Original Abstract of the Article :
To investigate the effects of medical treatment of endometriosis on concentrations of insulin and glucagon in comparison with those of androgens, 12 non-obese women with minimal endometriosis were randomly allocated to receive treatment with either danazol or the gonadotropin-releasing hormone analo...See full text at original site
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引用元：
https://doi.org/10.1530/acta.0.1230405

データ提供：米国国立医学図書館（NLM）

Endometriosis and Hormonal Effects on Insulin and Glucagon

Endometriosis, a condition where uterine tissue grows outside the uterus, can feel like a stubborn cactus in your desert. This study investigated the effects of two medications, danazol and goserelin, on insulin and glucagon levels in women with endometriosis. The researchers found that danazol significantly increased insulin and glucagon levels, while goserelin had no such effect. This suggests that danazol may have a different metabolic impact compared to goserelin.

Exploring the Metabolic Landscape

The study's findings offer valuable insights into the complex interplay between hormones and metabolism in women with endometriosis. It's like uncovering a hidden oasis within the desert of endometriosis, revealing the potential metabolic effects of different treatments.

Implications for Management of Endometriosis

Understanding the metabolic effects of various treatments for endometriosis could help doctors personalize treatment plans for women with this condition. It's like choosing the right path through the desert to optimize outcomes for each individual.

Dr. Camel's Conclusion

This study sheds light on the metabolic impact of different treatments for endometriosis, emphasizing the importance of considering individual metabolic needs when choosing the best treatment option.

Date :
  1. Date Completed 1990-12-27
  2. Date Revised 2019-07-16
Further Info :

Pubmed ID

2146853

DOI: Digital Object Identifier

10.1530/acta.0.1230405

Related Literature

Article Analysis
・Effective treatment of endometriosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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