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Development and in vitro/in vivo evaluation of etodolac controlled porosity osmotic pump tablets.

Author: Abd-ElbaryAhmed, Alaa-EldinAhmed Adel, TadrosMina Ibrahim

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Etodolac controlled porosity osmotic pump (CPOP) tablets were designed to provide zero-order release kinetics. Fructose-containing core tablets showed a significantly slower drug release rate.
Paper Details　
Original Abstract of the Article :
The aim of the current work was the design and evaluation of etodolac controlled porosity osmotic pump (CPOP) tablets exhibiting zero-order release kinetics. Variables influencing the design of (1) core tablets viz., (a) osmogent type (sodium chloride, potassium chloride, mannitol, and fructose) and...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134663/

データ提供：米国国立医学図書館（NLM）

Etodolac Controlled Porosity Osmotic Pump Tablets: A Camel's Guide to Sustained Drug Delivery

Sustained drug delivery is an important aspect of drug development, ensuring that medications are released into the body at a controlled rate. This study explored the design and evaluation of etodolac controlled porosity osmotic pump (CPOP) tablets, a novel drug delivery system designed to provide extended drug release.

Optimizing Drug Delivery: A Camel's Perspective on CPOP Tablets

The researchers successfully designed and evaluated CPOP tablets that exhibited zero-order release kinetics, ensuring a steady and prolonged release of etodolac. They optimized the formulation and manufacturing process, achieving a sustained release profile that lasted for 24 hours.

The Potential of CPOP Tablets: A Camel's Journey Through Drug Delivery

This research demonstrates the potential of CPOP tablets as a novel drug delivery system for etodolac, providing a sustained release profile with enhanced bioavailability and extended duration of effective plasma concentration.

Dr. Camel's Conclusion

This study highlights the potential of etodolac CPOP tablets for providing sustained drug delivery, offering a promising new approach to optimize drug release and improve therapeutic outcomes.
Date :
  1. Date Completed 2012-05-16
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21479749

DOI: Digital Object Identifier

PMC3134663

Related Literature

Article Analysis
・Side Effects of etodolac
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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