[Effect of flunarizine hydrochloride on striatal D-2 dopamine receptors].

Author: AsanumaM, NukinaI, OgawaN, SatoH, TakayamaH

Paper Details 
Original Abstract of the Article :
Flunarizine hydrochloride (FZ) is used to improve cerebral circulation and possesses Ca antagonistic effects. In recent years, this drug has been reported to induce parkinsonism and depressive symptoms as side effects, particularly in the elderly. Effects of FZ on dopamine receptors of the rat stria...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/2150791

データ提供:米国国立医学図書館(NLM)

Flunarizine and the Dopamine Dance

The brain is a complex and fascinating place, and dopamine is one of the key players in its intricate dance. Flunarizine, a drug used to improve cerebral circulation, has been found to have some surprising effects on dopamine receptors. This research delves into the intricacies of flunarizine's interactions with dopamine, particularly its impact on D-2 receptors.

Imagine a bustling desert marketplace filled with vendors and shoppers, each representing a different neurotransmitter. Flunarizine, like a wandering camel, interacts with the D-2 vendors, but not the D-1 vendors. Interestingly, this interaction is not a smooth handshake but more like a subtle push, an antagonistic effect. The study also observed that flunarizine's impact on D-2 receptors is more pronounced in older camels, suggesting a potential link to the onset of parkinsonism in the elderly.

Unraveling the Mystery of Parkinsonism

This research provides insights into the potential mechanisms underlying the development of parkinsonism, a debilitating neurological disorder. It suggests that flunarizine's interaction with dopamine receptors, particularly the D-2 receptors, could contribute to the onset of these symptoms, especially in older individuals. Further research is needed to fully understand the intricate relationships between flunarizine, dopamine, and parkinsonism.

A Reminder to Be Mindful of Medications and Age

This study reminds us that even seemingly innocuous medications can have unforeseen effects, especially as we age. The interaction between flunarizine and dopamine receptors illustrates the delicate balance within our bodies. It's important to be aware of potential side effects and discuss any concerns with your doctor.

Dr.Camel's Conclusion

This research highlights the complexity of brain chemistry and the need for ongoing research to understand the intricate interactions between medications, neurotransmitters, and age-related conditions. It's a reminder to appreciate the delicate dance of life and to seek expert advice when navigating the vast desert of medical knowledge.

Date :
  1. Date Completed 1991-05-17
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2150791

DOI: Digital Object Identifier

2150791

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SNS
PICO Info
in preparation
Languages

Japanese

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