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Modulation of Cisplatin toxicity by glutathione.
Author: BernsteinE, CookJ, CookS, DelucaA, FisherJ, GlassJ, PassH
Original Abstract of the Article :
Organ toxicity is the major limiting factor associated with chemotherapeutic treatment of malignancy. By raising the toxicity threshold of the organ to the detrimental effects of chemotherapeutic agents, larger and possibly curative doses may be administered without unacceptable side effects. Glutat...See full text at original site
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引用元:
https://doi.org/10.3892/ijo.7.2.353
データ提供:米国国立医学図書館(NLM)
Glutathione: A Potential Protector Against Cisplatin Toxicity
Cisplatin, a powerful chemotherapy drug used to treat various cancers, is notorious for its severe side effects, particularly organ toxicity. This research investigates the potential protective effects of glutathione, a naturally occurring antioxidant, against cisplatin-induced toxicity. The researchers explored whether administering glutathione alongside cisplatin could reduce the drug's harmful effects on the body.
A Protective Oasis in the Desert of Chemotherapy
The study found that glutathione injections, given before and after cisplatin treatment, significantly reduced the lethal effects of cisplatin. Furthermore, glutathione administration alongside cisplatin markedly reduced renal toxicity, suggesting that it may act as a shield against the damaging effects of the drug. However, the study also observed that glutathione slightly increased tumor size, indicating the need for further research to optimize its use in conjunction with cisplatin.
Navigating the Complexities of Chemotherapy
This research highlights the potential of glutathione as a protective agent against cisplatin-induced toxicity. However, the study also underscores the need for careful consideration of glutathione's potential impact on tumor growth. Further research is required to optimize the use of glutathione in combination with cisplatin, ensuring maximum benefit and minimal harm. This research is like a camel caravan navigating the complex and often treacherous landscape of chemotherapy, seeking ways to improve treatment outcomes while minimizing side effects.
Dr. Camel's Conclusion
This research offers a promising glimpse into the potential of glutathione as a protective agent against the harsh side effects of cisplatin. While further research is needed to optimize its use, this study provides hope for a future where chemotherapy can be more effectively targeted, minimizing harm and maximizing benefit for patients. As we continue our journey through the desert of cancer research, we seek innovative solutions to improve the lives of those battling this devastating disease.
Date :
- Date Completed 2012-10-02
- Date Revised 2019-06-06
Further Info :
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