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Effect of D-cycloserine and valproic acid on the extinction of reinstated fear-conditioned responses and habituation of fear conditioning in healthy humans: a randomized controlled trial.

Author: FujiiTakeshi, HonmaMotoyasu, KimYoshiharu, KuriyamaKenichi, SoshiTakahiro

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A single dose of DCS or VPA might enhance exposure-based cognitive therapy of anxiety disorders by reducing the vulnerability to reinstatement and preventing relapses of fear-conditioned responses.
Paper Details　
Original Abstract of the Article :
RATIONALE: Although the effects of D: -cycloserine (DCS) and valproic acid (VPA) on the facilitation of the extinction of fear-conditioned memory have been elucidated in animals, these effects have not been clearly confirmed in humans. OBJECTIVE: This study aimed to determine the effect of DCS (100...See full text at original site
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引用元：
https://doi.org/10.1007/s00213-011-2353-x

データ提供：米国国立医学図書館（NLM）

D-Cycloserine and Valproic Acid: A Promising Oasis in the Desert of Fear

Fear conditioning, the process of learning to associate a neutral stimulus with a negative outcome, can be a debilitating experience. This research explores the potential of D-cycloserine (DCS) and valproic acid (VPA) to facilitate the extinction of fear-conditioned responses in humans. The study used a randomized controlled trial to compare the effects of DCS and VPA with placebo on the extinction and acquisition of fear-conditioned memory.

A Hopeful Oasis: DCS and VPA Facilitate Extinction

The study found that both DCS and VPA facilitated the extinction of fear-conditioned responses, reducing the vulnerability to reinstatement and preventing relapses of fear-conditioned responses. These findings suggest that DCS and VPA could have therapeutic potential for treating anxiety disorders, offering a potential oasis in the desert of fear and anxiety.

A Path Towards Healing: Harnessing the Power of Extinction

This research underscores the importance of extinction learning in managing anxiety disorders, highlighting the potential of DCS and VPA to facilitate this crucial process. It's like finding a pathway to healing in the desert of fear, where extinction learning can help individuals overcome debilitating anxieties.

Dr. Camel's Conclusion

This research investigates the effects of D-cycloserine (DCS) and valproic acid (VPA) on the extinction of fear-conditioned responses in humans. The study demonstrates the potential of these agents to facilitate extinction learning, suggesting their therapeutic value in treating anxiety disorders and offering a promising approach for managing fear and anxiety.

Date :
  1. Date Completed 2012-03-19
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21594560

DOI: Digital Object Identifier

10.1007/s00213-011-2353-x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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