Intermittent or daily montelukast versus placebo for episodic asthma in children.

Author: BozaMaria L, GurnerDeborah M, KnorrBarbara A, NelsenLinda M, PhilipGeorge, ReissTheodore F, RobertsonColin F, SmugarSteven S, ValovirtaErkka, VerbruggenNadia

Paper Details 
Original Abstract of the Article :
BACKGROUND: No standard, optimal treatment exists for severe intermittent (ie, episodic) asthma in children. However, evidence suggests that both daily and episode-driven montelukast are effective for this phenotype. OBJECTIVE: To assess the regimen-related efficacy of montelukast in treating pedia...See full text at original site
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引用元:
https://doi.org/10.1016/j.anai.2011.01.017

データ提供:米国国立医学図書館(NLM)

Episodic Asthma in Children: Montelukast's Effectiveness Under Scrutiny

The world of pediatric asthma is a vast and sometimes dusty desert, with many researchers searching for the perfect oasis of treatment. This study, like a camel caravan venturing into uncharted territory, sought to determine the best way to use montelukast in children with episodic asthma, a condition where symptoms flare up occasionally like a desert storm. The researchers conducted a large-scale study with two different montelukast regimens: daily and episodic (only when symptoms arise). They found that neither regimen significantly reduced the number of asthma episodes leading to a full-blown attack, despite some positive trends in symptom reduction. This is an important finding, as it challenges the conventional wisdom of daily use for montelukast in episodic asthma.

Montelukast's Efficacy: A Desert Mirage?

After a year of tracking asthma episodes, the researchers found that daily montelukast and episode-driven montelukast did not significantly outperform placebo. However, daily montelukast did show some positive effects during the 12-day treatment period of asthma episodes, suggesting a possible role in symptom management during acute exacerbations. This finding requires further exploration, like a lone camel seeking a hidden waterhole in the desert.

Navigating the Shifting Sands of Asthma Treatment

This study reminds us that the quest for the ideal asthma treatment is an ongoing one. While montelukast may not be the magic bullet we once hoped for, it could still play a valuable role in symptom management during asthma flares. As we continue to explore the vast landscape of asthma research, we need to be aware of the limitations of current treatments and remain open to new possibilities.

Dr. Camel's Conclusion

It seems the quest for a clear-cut solution for episodic asthma in children continues. While montelukast didn't deliver a knockout punch in this study, its role in managing symptom flares during asthma episodes shouldn't be ignored. As we continue our journey through the desert of asthma research, we'll keep searching for new approaches and better treatments. After all, a good camel always knows how to adapt to the changing landscape.

Date :
  1. Date Completed 2011-08-02
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

21624752

DOI: Digital Object Identifier

10.1016/j.anai.2011.01.017

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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