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Prednisolone-induced changes in gene-expression profiles in healthy volunteers.

Author: AlkemaWynand, BauerschmidtSusanne, DokterWim H A, FleurenWilco W M, NässanderUlla, ToonenErik J M, van LieropMarie-José C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Glucocorticoids (GCs) have a significant impact on gene expression and cell subpopulations, leading to both efficacy and side effects.
Paper Details　
Original Abstract of the Article :
Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which the metabolic side effects are most evident. Relatively little is known about their effect on gene-expression in...See full text at original site
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引用元：
https://doi.org/10.2217/pgs.11.34

データ提供：米国国立医学図書館（NLM）

Prednisolone and Gene Expression: A Journey Through the Sands of Molecular Mechanisms

Prednisolone, a potent anti-inflammatory and immunosuppressive drug, is a valuable tool in managing a wide range of conditions. However, its use can also lead to various side effects. This study delves into the molecular mechanisms underlying prednisolone's effects, examining its impact on gene expression in healthy volunteers. It explores the intricate interplay between prednisolone and cellular processes, providing insights into the potential for personalized medicine and minimizing adverse effects.

Prednisolone's Impact on Gene Expression

This study reveals that prednisolone significantly alters gene expression profiles in healthy volunteers. The researchers identified specific genes that were upregulated and downregulated following prednisolone administration, suggesting a complex interplay between the drug and cellular processes. These findings provide valuable insights into the molecular mechanisms underlying prednisolone's therapeutic and adverse effects.

Navigating the Desert of Personalized Medicine

This study highlights the importance of understanding the molecular mechanisms underlying drug action. By unraveling the intricate interplay between medications and cellular processes, we can develop more targeted and personalized therapies, minimizing adverse effects and maximizing treatment efficacy. As we continue to explore the vast desert of molecular mechanisms, this research provides valuable insights into the potential for precision medicine and optimizing patient outcomes.

Dr. Camel's Conclusion

This study reveals the intricate interplay between prednisolone and gene expression, providing valuable insights into the molecular mechanisms underlying its therapeutic and adverse effects. It emphasizes the importance of understanding these mechanisms to develop more personalized and effective therapies, navigating the vast desert of personalized medicine and optimizing patient outcomes.

Date :
  1. Date Completed 2011-11-23
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

21635145

DOI: Digital Object Identifier

10.2217/pgs.11.34

SNS
PICO Info
in preparation
Languages

English

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