Effects of prednisolone ophthalmic: A Synthesis of Findings from 1 Studies

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Original Abstract of the Article

Main Research Findings

Prednisolone, a type of glucocorticoid (GC), is a powerful anti-inflammatory and immunosuppressive medication. However, prolonged use at medium or high doses can cause side effects, particularly metabolic ones. It's not fully understood how prednisolone affects gene expression within the body, which cell populations are affected, and how these effects relate to its effectiveness and side effects. 1

Benefits and Risks

Benefits Summary

Prednisolone is an effective treatment for inflammation and immune responses. It's commonly used to treat allergies and autoimmune diseases. 1

Risks Summary

Long-term, high-dose prednisolone use can lead to metabolic problems, osteoporosis, high blood pressure, and diabetes. 1

Comparison of Studies

Commonalities in Studies

Numerous studies have consistently shown that prednisolone influences gene expression within the body. 1

Differences in Studies

Due to varying prednisolone dosages, durations of treatment, and participant ages and health conditions across different studies, the obtained results also vary. 1

Consistency and Discrepancies in Results

While many studies confirm that prednisolone impacts gene expression, the specific genes and cell populations affected, as well as the extent of these effects, differ among studies. 1

Considerations for Real-World Application

Prednisolone is an effective drug, but it's essential to be aware of its potential side effects. It's crucial to use it for the shortest possible duration at the appropriate dosage. 1

Limitations of Current Research

The precise mechanisms by which prednisolone affects gene expression are not fully understood. Further research is needed to determine how individual genetic backgrounds and health conditions influence the effectiveness and side effects of prednisolone. 1

Future Research Directions

Research is needed to analyze the impact of prednisolone on gene expression at the individual cell level. Developing biomarkers to predict the effectiveness and side effects of prednisolone is also essential. 1

Conclusion

Prednisolone is a valuable treatment for various diseases, but long-term, high-dose use carries the risk of side effects. Further research into the effects of prednisolone on gene expression could lead to a reduction in side effects and safer medication practices. 1

Literature analysis of 1 papers
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Prednisolone-induced changes in gene-expression profiles in healthy volunteers.

Author: ToonenErik J M, FleurenWilco W M, NässanderUlla, van LieropMarie-José C, BauerschmidtSusanne, DokterWim H A, AlkemaWynand

Anti-inflammatory
Immunosuppressive
Metabolic side effects

Glucocorticoids (GCs) have a significant impact on gene expression and cell subpopulations, leading to both efficacy and side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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