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Exemestane for breast-cancer prevention in postmenopausal women.

Author: , Alés-MartínezJosé E, CheungAngela M, ChlebowskiRowan T, FabianCarol J, FarmerPatricia, GarberJudy E, GelmonKaren A, GossPaul E, IngleJames N, JohnsonKaren C, MartinLisa W, MaunsellElizabeth, McTiernanAnne, PujolPascal, RichardsonHarriet, RobbinsJohn, SartoGloria E, TuDongsheng, Wactawski-WendeJean, WinquistEric

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Exemestane significantly reduced invasive breast cancers in postmenopausal women at moderately increased risk for breast cancer. Exemestane was associated with no serious toxic effects and only minimal changes in health-related quality of life.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Tamoxifen and raloxifene have limited patient acceptance for primary prevention of breast cancer. Aromatase inhibitors prevent more contralateral breast cancers and cause fewer side effects than tamoxifen in patients with early-stage breast cancer. METHODS: In a randomized, placebo-cont...See full text at original site
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引用元：
https://doi.org/10.1056/NEJMoa1103507

データ提供：米国国立医学図書館（NLM）

Exemestane for Breast Cancer Prevention: A New Hope for Postmenopausal Women

This study explores the effectiveness of exemestane, an aromatase inhibitor, in preventing breast cancer in postmenopausal women at moderately increased risk.

Preventing Breast Cancer: New Frontiers in Treatment

The study aimed to determine if exemestane could significantly reduce the incidence of invasive breast cancer in postmenopausal women with specific risk factors.

Significant Reduction in Breast Cancer

The study found that exemestane significantly reduced the annual incidence of invasive breast cancer by 65% compared to placebo. The drug was well-tolerated, with minimal side effects and no significant impact on quality of life.

Health Implications and Prevention Strategies

This research offers a promising new option for breast cancer prevention in postmenopausal women at moderately increased risk. Exemestane demonstrates significant effectiveness with minimal side effects.

Dr.Camel's Conclusion

Imagine a desert oasis where a new spring has been discovered, offering a source of protection against the harshness of the environment. This study is like discovering a new spring, exemestane, which provides a powerful defense against breast cancer.
Date :
  1. Date Completed 2011-06-30
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

21639806

DOI: Digital Object Identifier

10.1056/NEJMoa1103507

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PICO Info
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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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