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Mechanisms of estrogens' dose-dependent neuroprotective and neurodamaging effects in experimental models of cerebral ischemia.

Author: StromJakob O, TheodorssonAnnette, TheodorssonElvar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This article reviews the proposed mechanisms of estrogen actions in cerebral ischemia, highlighting the dose-dependent paradoxical effects of estrogens. Physiological estrogen concentrations are neuroprotective, while supraphysiological concentrations augment damage from cerebral ischemia.
Paper Details　
Original Abstract of the Article :
Ever since the hypothesis was put forward that estrogens could protect against cerebral ischemia, numerous studies have investigated the mechanisms of their effects. Despite initial studies showing ameliorating effects, later trials in both humans and animals have yielded contrasting results regardi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111617/

データ提供：米国国立医学図書館（NLM）

The Duality of Estrogens in Cerebral Ischemia: A Balancing Act

The world of neurobiology is filled with intricate complexities, much like a shimmering oasis with hidden depths. This article explores the fascinating duality of estrogens in the context of cerebral ischemia, a condition that occurs when blood flow to the brain is interrupted. The authors meticulously review the available evidence, examining the dose-dependent effects of estrogens on brain cells and the mechanisms underlying their neuroprotective and neurodamaging actions. This research provides a nuanced understanding of the complex relationship between estrogens and brain health in the setting of stroke.

Estrogens and Brain Health: A Delicate Balance

This study reveals the intricate dance between estrogens and brain health, highlighting the dose-dependent nature of their effects in cerebral ischemia. The authors emphasize the importance of maintaining physiological estrogen levels to protect the brain from damage, while cautioning against supraphysiological levels that may exacerbate injury. This research underscores the need for a balanced approach to understanding the role of estrogens in brain health.

Navigating the Estrogen Landscape: A Journey of Understanding

For individuals seeking to understand the role of estrogens in brain health, it's crucial to recognize the complexities involved. This research provides valuable insights into the dose-dependent nature of estrogen's effects and the potential risks and benefits associated with hormone replacement therapy. Consulting with a healthcare professional to discuss individual needs and risks is essential in making informed decisions about estrogen therapy.

Dr. Camel's Conclusion

This article offers a comprehensive overview of the complex interplay between estrogens and brain health in the context of cerebral ischemia. It's a reminder that the desert of neurobiology is filled with hidden nuances and that understanding the dose-dependent effects of hormones is essential for optimizing brain health.

Date :
  1. Date Completed 2015-01-19
  2. Date Revised 2022-06-06
Further Info :

Pubmed ID

21673906

DOI: Digital Object Identifier

PMC3111617

SNS
PICO Info
in preparation
Languages

English

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