Paper Details

  1. Home
  2. Paper Details

Local failure in patients treated with radiotherapy and multidrug chemotherapy for small cell lung cancer.

Author: BrodinO, NouE, RiknerG, SteinholtzL

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study of 53 patients with small cell lung cancer examined the effectiveness of chemotherapy and radiation therapy. The study found that a high percentage of patients experienced recurrence within the treated area, suggesting that the radiation dose was insufficient to eliminate the tumor. While increasing radiation dose could potentially improve local control, a significant number of patients developed cancer in other parts of the body, suggesting that improving local treatment alone might not be enough to improve long-term survival. The study also found that higher doses of radiation increased the risk of severe side effects. This highlights the challenge of finding a balance between improving cancer control and minimizing side effects in treating this type of cancer.
Paper Details　
Original Abstract of the Article :
Fifty-three patients with small cell carcinoma of the lung were treated with chemotherapy and radiotherapy, 40 Gy in the chest tumour. Intrathoracic failure occurred in 89% of the cases with extensive disease and in 60% of those with limited disease. Since 86% of all failures were localized within t...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.3109/02841869009092993

データ提供：米国国立医学図書館（NLM）

Small Cell Lung Cancer: A Challenging Journey Through the Desert of Cancer

Small cell lung cancer (SCLC), an aggressive form of lung cancer, requires comprehensive treatment approaches. This study investigates the local failure rates in patients with SCLC treated with a combination of radiotherapy and multidrug chemotherapy. The researchers analyzed data from 53 patients, assessing the incidence of intrathoracic failure and the impact of treatment techniques on outcomes. Their findings highlight the high local failure rate, suggesting that the radiation dose used in the study may have been insufficient for tumor eradication.

Radiotherapy for SCLC: A Balancing Act in the Desert of Cancer Treatment

The study underscores the importance of optimizing radiotherapy techniques and potentially increasing radiation dose for SCLC treatment. The authors note the high local failure rate, indicating that the current approach may not be sufficient for tumor eradication. While increasing the radiation dose may improve local control, the authors also caution against excessive dose escalation due to the risk of treatment toxicity.

Navigating SCLC: A Desert of Challenges and Hope

This study highlights the complexity of managing SCLC, emphasizing the need for multidisciplinary approaches that address both local and distant disease. While radiotherapy plays a crucial role in treatment, ongoing research is necessary to develop more effective strategies for controlling both local and distant disease. Patients with SCLC should seek comprehensive care from a multidisciplinary team, including oncologists, radiation oncologists, and other specialists, to ensure optimal management and maximize their chances of survival.

Dr.Camel's Conclusion

This study sheds light on the challenges of managing SCLC, highlighting the high local failure rates observed with current treatment approaches. The authors emphasize the need for optimizing radiotherapy techniques and considering dose escalation while balancing the risk of treatment toxicity. The study underscores the importance of multidisciplinary care and ongoing research to improve outcomes for patients with SCLC.

Date :
  1. Date Completed 1990-12-12
  2. Date Revised 2019-09-03
Further Info :

Pubmed ID

2171595

DOI: Digital Object Identifier

10.3109/02841869009092993

Related Literature

Article Analysis
・Effective treatment of lung cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.