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[Protective effects of d-chlorpheniramine maleate pre-treatment against acute side effects of Irinotecan(CPT- 11)].

Author: HashimotoMirai, HiraikeMikako, HondaShinobu, MisumiNobuhiro, NabeshimaAya, NawataFusako, TakaseIzumi, TanigawaKayoko

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Pre-administration of d-Chlorpheniramine maleate (d-CM) significantly reduced the number of patients experiencing cholinomimetic side effects after Irinotecan (CPT-11) administration.
Paper Details　
Original Abstract of the Article :
It is wellknown that cholinomimetic side effects, such as sedation, abdominal pain, nasal flow and watery eyes, may develop in patients in the early stage of Irinotecan (CPT-11) administration; however, there have been no investigations concerning methods for preventing the development of these side...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/21772100

データ提供：米国国立医学図書館（NLM）

Irinotecan and d-Chlorpheniramine Maleate: A Protective Partnership

Irinotecan, a chemotherapy drug used to treat various cancers, can cause unpleasant side effects such as abdominal pain, nausea, and diarrhea. This research explores the potential of pre-treating patients with d-chlorpheniramine maleate (d-CM), an antihistamine, to prevent these side effects. It's like adding a shield of protection against the harsh effects of chemotherapy.

A Shield Against Chemotherapy Side Effects

The study found that pre-treating patients with d-CM significantly reduced the incidence of side effects associated with irinotecan. It's like building a wall of defense to protect against the enemy's attacks. The authors believe that d-CM may help to block the release of chemicals that cause these side effects, effectively shielding patients from their unwanted effects. It's like having a magic potion that neutralizes the harmful chemicals, allowing the patient to experience the benefits of chemotherapy without the burden of its side effects.

A New Approach to Cancer Treatment

This research offers a promising new approach to managing the side effects of chemotherapy. It's like finding a hidden spring of relief in the harsh desert of cancer treatment. The use of d-CM as a pre-treatment could significantly improve the quality of life for patients undergoing chemotherapy, allowing them to better tolerate the treatment and focus on recovery. This study is a testament to the ongoing search for ways to improve cancer treatment, making it more effective and tolerable for patients.

Dr.Camel's Conclusion

This research highlights the potential benefits of d-CM as a pre-treatment for irinotecan-induced side effects. It's like a protective oasis in the desert of chemotherapy, providing a shield against the harsh effects of treatment. This study is a testament to the ongoing efforts to improve cancer treatment, making it more tolerable and effective for patients.

Date :
  1. Date Completed 2011-08-05
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

21772100

DOI: Digital Object Identifier

21772100

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Languages

Japanese

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